Müge KİRAY, Emel BERKSOY, Yüksel BICILIOĞLU, Börteçin EYGİ, Gamze GÖKALP, Neslihan ZENGİN, Şahin İŞCAN, Orhan GÖKALP, Ali GÜRBÜZ, Burcu AÇIKGÖZ

Alt ekstremite iskemi reperfüzyonu sonrası karaciğer hasarı ne kadar önemlidir? Sıçan modelinde deneysel bir çalışma

Amaç: Bu çalışmada bir sıçan modelinde alt ekstremite iskemi reperfüzyonunun karaciğer üzerindeki etkisi ile karaciğerin spesifik iskemi reperfüzyonunun karaciğer üzerindeki etkisi karşılaştırıldı. Çalışma planı: Otuz adet Sprague-Dawley tipi erkek sıçan 10’arlı olarak rastgele üç gruba ayrıldı: kontrol grubu (Grup 1), alt ekstremite iskemi reperfüzyon grubu (Grup 2) ve karaciğer iskemi reperfüzyon grubu (Grup 3). Grup 2’de sol alt ekstremiteye bir saat süreyle iskemi uygulandı. Grup 3’te karaciğere bir saat süreyle iskemi ve ardından 24 saat süreyle reperfüzyon uygulandı. Reperfüzyon sonrası karaciğer dokuları çıkarıldı ve gruplar biyokimyasal ve histolojik olarak değerlendirildi. Bulgular: Karaciğer malondialdehit düzeyleri Grup 2 ve Grup 3’te kontrol grubuna kıyasla anlamlı olarak yüksek idi (p

How important is the damage to the liver after lower limb ischemia-reperfusion? An experimental study in a rat model

Background: The aim of this study was to compare the effect of lowerextremity ischemia reperfusion on the liver and the effect of ischemiareperfusionon the liver itself in a rat model.Methods: Thirty Sprague-Dawley male rats were randomly divided intothree groups including 10 in each group: sham (Group 1), lower limbischemia-reperfusion (Group 2), and liver ischemia-reperfusion (Group 3).In Group 2, one hour of left lower limb ischemia was performed. InGroup 3, one hour of ischemia in the liver was performed, followed by24 hours of reperfusion. After reperfusion, the liver tissues were removed,and the groups were evaluated biochemically and histologically.Results: The liver malondialdehyde levels were significantly higherin Groups 2 and 3 than in the sham group (p

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