Arı Sütünün Tüketici Egzersize Bağlı Oksidatif Stres Üzerindeki Rolü

Bu çalışmada, Arı Sütü (RJ)'nin sıçan dokularındaki tüketici yüzme egzersizinin neden olduğu oksidatif stres üzerindeki etkileri değerlendirildi. Metodlar: Yirmi dört adet erkek Wistar albino sıçan rastgele dört deney grubuna ayrıldı: Sedanter kontrol (SC); 100 mg kg-1 RJ uygulanmış SC (SC + RJ); tüketici yüzme egzersiz grubu (E); 100 mg kg-1 RJ uygulanmış tüketici yüzme egzersiz grubu (E + RJ). 100 mg kg-1 RJ içme suyunda çözüldü. SC + RJ ve E + RJ gruplarındaki sıçanlara, iki hafta boyunca günde bir kez ağızdan RJ (100 mg kg-1) verildi. E ve E + RJ gruplarındaki sıçanlar çalışmanın 14. gününde akut tüketici yüzme egzersizine tabi tutulduktan sonra tüm grupların oksidatif stres ile ilgili bazı biyokimyasal parametreleri ölçüldü. Bulgular: Alanin aminotransferaz (ALT), aspartat aminotransferaz (AST), alkalin fosfataz (ALP), kan üre azotu (BUN) ve kreatinin (CRE) seviyelerinin aktiviteleri, egzersiz yapılan sıçanlarda, sedanter sıçanlara kıyasla önemli ölçüde artmıştır (P < 0.05). RJ ile tedavi edilen sıçanlarda kas ve hepatik dokuların azalmış süperoksit dismutaz (SOD), glutatyon peroksidaz (GSHPx) ve katalaz (CAT) aktiviteleri önemli ölçüde artmış ve kas, hepatik ve böbrek dokularının yüksek malondialdehit (MDA) seviyeleri önemli ölçüde azalmıştır (P < 0.05). Sonuç: Sonuç olarak, bu çalışmada, tüketici egzersiz sonrası oluşan dokular üzerindeki oksidatif hasara karşı RJ'nin koruyucu etkileri gözlenmiştir.

Anahtar Kelimeler:

Arı sütü, Karaciğer, Böbrek, İskelet kası, Tüketici egzersiz, Antioksidan

The Role of Royal Jelly on Exhaustive Exercise-Induced Oxidative Stress

In this study, the effects of Royal Jelly (RJ) on oxidative stress caused by exhaustive swimming exercise in rat tissues were evaluated. Methods: Twenty four male Wistar albino rats were indiscriminately distributed into four experimental groups: Sedentary control (SC); SC with administration of RJ (100 mg kg-1) (SC + RJ); exhaustive swimming exercise (E); Exhaustive swimming exercise with administration of RJ (100 mg kg-1) (E + RJ). 100 mg kg-1 of RJ were dissolved in drinking water. Rats in the SC+RJ and E+RJ groups supplemented with RJ (100 mg kg-1) orally once a day for two weeks. Rats in groups E and E+RJ subjected to acute exhaustive swimming exercise on the 14th day of the study, then some biochemical parameters related to oxidative stress of all groups were measured. Results: The activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), blood urea nitrogen (BUN) and creatinine (CRE) levels significantly raised in the exercised rats compared with the sedentary rats (P < 0.05). The decreased superoxide dismutase (SOD), glutathione peroxidase (GSHPx), and catalase (CAT) activities of muscular and hepatic tissues significantly increased and the high malondialdehyde (MDA) levels of muscular, hepatic and kidney tissues significantly reduced in exercised rats treated with RJ (P < 0.05). Conclucion: Collectively, in this study, protective effects of RJ on tissues against oxidative damage after exhaustive exercise were observed.

Keywords:

Royal Jelly, Liver, Kidney, Skeletal muscle, Exhaustive exercise, Antioxidant, Arı sütü, Karaciğer, Böbrek, İskelet kası, Tüketici egzersiz, Antioksidan, Arı sütü Arı sütü, Karaciğer, Böbrek, İskelet kası, Tüketici egzersiz, Antioksidan,

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