Taha T. Bekçi, Bülent Deveci, Güler Karaağaç, Yalçın Karakoca, Nadir Koçak

OSAS’lı Hastalarda Cinsiyetin Hipertansiyon Üzerine Etkisi

Amaç: Bu çalışmada OSAS'lı hastalarda hipertansiyon ve RPP (rate pressure product) üzerinde cinsiyetin etkilerini araştırmayı amaçladık. Metod: Tüm hastalara bir gece boyunca diagnostik polisomnografi uygıulandı. OSAS teşhisi konulan hastalar çalışmaya dahil edildi. Uyku süreçleri ve respiratuar durumlar polisomnografi bulgularına göre skorlandı. OSAS'lı hastalarda cinsiyetin tansiyon üzerindeki etkileri istatiksel olarak analiz edildi. Bulgular: Çalışmaya 280 erkek ve 67 kadın olmak üzere 347 hasta dahil edildi. Kadınlarda yaş ortalaması 50±15, erkeklerde 48±12'idi. Vücut kitle indeksi (The body mass index (BMI)) kadınlarda 28±6 kg/m² , erkeklerde 28±5 kg/m² olarak bulundu. Burada erkek gruplarında maksimum sistolik kan basıncı ve RPP ile AHI (apnea/hypopnea index) arasında pozitif bir ilişki (p<0.01), kadın gruplarında ise min PTT ile AHI arasında pozitif bir ilişki bulundu (p<0.01); ancak kadınlarda max SBP ile AHI arasında ilşki bulunamadı. Sonuç: Bu çalışma SBP ile obstruktif sleep apne arasındaki ilişkiye ilişkin önceki bulguları doğrulamaktadır. Bu ilişki erkeklerde açık olarak görülürken kadınlarda bulunamamıştır. Bu bilgiler OSAS'lı hastalarda hipertansiyona yatkınlıkta cinsiyet farklılıklarının etkisinin olası olduğunu göstermektedir. Anahtar kelimeler: Obstruktif Uyku Apnesi, Hipertansiyon, Cinsiyet Etkisi

Anahtar Kelimeler:

Obstruktif Uyku Apnesi, Hipertansiyon, Cinsiyet Etkisi

The Effect of Gender on Hypertension in OSAS Patients

Objective: There are limited data about the effect of gender on the tension and rate pressure product (RPP) in patients with OSAS. The aim of the present study was to explore the effect of gender on hypertension (HT) and RPP in patients with OSAS. Methods: A diagnostic polysomnography was performed in all patients for overnight. OSAS diagnosed patients were included in this study. Sleep stages and respiratory events were manually scored. According to the findings of polysomnography, the effect of gender on tension in patients with OSAS was statistically analyzed. Results: Three hundred fourty seven patients consisting of 280 males and 67 females with OSAS were included in the present study. The mean age was 50±15 years in females and 48±12 years in males. The body mass index (BMI) was 28±6 kg/m2 in females and 28±5 kg/m2 in males. There was a positive correlation between the apnea/hypopnea index (AHI) with max systolic blood pressure (SBP) and RPP (p<0.01) in the male group, and a positive correlation between AHI with min PTT in the female group (p<0.01); however, there was no correlation between AHI and max SBP in females (p>0.05). Conclusion: The present study confirms previous findings of a relationship between obstructive sleep apnea with SBP. This relationship was evident in males but not identifiable in these females.These data suggest a possible gender difference in susceptibility to hypertension development in OSAS. Key words: Obstructive Sleep Apnea Syndrome, Hypertension, Gender Effect

Keywords:

Obstructive Sleep Apnea Syndrome, Hypertension, Gender Effect,

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Corresponding author: Nadir KOÇAK, MD
Konya Education and Research Hospital, KONYA
Phone: 90 332 322 25 07/90 506 544 91 28
e-mail: nadirkocak@yahoo.com