Özlem ELKIRAN, Yılmaz TABEL, Ünsal ÖZGEN, Cemşit KARAKURT, Gülendam KOÇAK

Hodgkin Hastalığında Paraneoplastik Sendrom Olarak Nefrotik Sendrom: Olgu Sunumu

Nefrotik sendrom, Hodgkin hastalığında iyi bilinen ancak nadir görülen bir paraneoplastik sendromdur. Nefrotik sendrom malignensiden önce, malignensi ile eşzamanlı veya malignensiyi izleyerek ortaya çıkabilir. Minimal lezyon hastalığı en sık görülen renal lezyondur. Paraneoplastik sendromun immunupatolojik mekanizması tam olarak bilinmemektedir. Ancak, glomerular bazal membran geçirgenliğini değiştiren sitokinlerin salınımına yol açan bir T hücre disfonksiyonunun olduğu düşünülmektedir. Sıklıkla yalnızca malignensi tedavisinin yeterli olması nedeni ile paraneoplastik sendromun tanımlanması önemlidir. Bu makalede Hodgkin hastalığı tanısından 16 ay önce nefrotik sendrom kliniğini ile başvuran 3 yaşında erkek olgu sunuldu. Anahtar kelimeler: Paraneoplastik Sendrom, Hodgkin Hastalığı

Anahtar Kelimeler:

Paraneoplastik Sendrom, Hodgkin Hastalığı

Nephrotic Syndrome as a Paraneoplastic Syndrome of Hodgkin’s Disease: Case Report

Nephrotic syndrome is a known but rare paraneoplastic syndrome accompanying Hodgin's disease. Nephrotic syndrome may precede, coincide or follow the diagnosis of malignancy. Minimal change glomerular nephropathy is the most frequently observed renal lesion. The immunopathological background of this entity is unknown. But, it is thought that T-cell dsyfunction leads to a secretion of cytokines which alters the permeability of the glomerular basement membrane. The clear recognition of a paraneoplastic syndrome is important, as it is often only necessary to treat the malignancy. In this report, we describe a-3-year-old boy who presented as nephrotic syndrome at 16 months prior to the diagnosis of Hodgin's disease . Key words: Paraneoplastic Syndrome, Hodgkin's Disease

Keywords:

Paraneoplastic Syndrome, Hodgkin's Disease,

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