Türkan TOĞAL, Mustafa Said AYDOĞAN, Kalender KARAHAN, Ali ŞENER, Muharrem UÇAR, M Özcan ERSOY

Amyotrofik Lateral Skleroz Olgularında Yoğun Bakım Tedavisi

Amyotrofik lateral skleroz (ALS) medülla spinalis, beyin sapı ve beynin motor korteksindeki motor nöronların ilerleyici dejeneratif bir hastalığıdır. Bilinç bozukluğu yapmadan yaygın kas güçsüzlüğü, yutma güçlüğü ve özellikle solunum güçlüğü yaratan bir hastalıktır. Bu yazıda ağır solunum yetmezliği ve pnömoniyle yoğun bakımda takip ve tedavi edilen üç ALS tanısı almış olgunun takip ve tedavisi sunulmuştur. Anahtar kelimeler: Amyotrofik Lateral Skleroz, Motor Nöron Hastalığı, Yoğun Bakım, Pnömoni

Anahtar Kelimeler:

Amyotrofik Lateral Skleroz, Motor Nöron Hastalığı, Yoğun Bakım, Pnömoni

Critical Care Management of Amyotrophic Lateral Sclerosis Cases

Amyotrophic lateral sclerosis (ALS) is a progressive, neurodegenerative disease caused by the degeneration of motor neurons, including medulla spinalis, cerebellum and motor cortex of central nervous system that control voluntary muscle movement. The disease usually does not affect cognitive abilities, but makes muscle weakness, difficulty in swallowing and chewing especially breathing. Here in, we report the critical care management of three ALS case with pneumonia and severe respiratory distress. Key words: Amyotrophic Lateral Sclerosis, Motor Neuron Disease, Critical Care, Pneumonia

Keywords:

Amyotrophic Lateral Sclerosis, Motor Neuron Disease, Critical Care, Pneumonia,

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Brown RH. Adult and juvenile Amyotrophic Lateral Sclerosis and related motor neuron diseases. Eds: Engel AG, Armstrong CF. In: Myology, McGraw-Hill; 2004:1865-88.
Sarchielli P, Pelliccioli GP, Tarducci R, et al. Magnetic resonance imaging and 1H-magnetic resonance spectroscopy in amyotrophic lateral sclerosis. Neuroradiology 2001;43: 189-197.
Beal MF. Mitochondria, free radicals, and neurodegeneration. Curr Opin Neurobiol. 1996;6(5):661-6. Review.
Bowen BC, Pattany PM, Bradley WG, et al. MR imaging and localized proton spectroscopy of the precentral gyrus in ALS. Am J Neuroradiol. 2000;21(4):647-58.
Bensimon G, Lacomblez L, Meininger V. A controlled trial of riluzole in amyotrophic lateral sclerosis. N Engl J Med. 19943;330(9):585-91.
Phukan J, Hardiman O. The management of amyotrophic lateral Sclerosis. Review. J Neurol 2009; 256:176–86
7.Lechtzin N; Rothstein J; Clawson L; Diette GB, Wiener CM. Amyotrophic lateral sclerosis: evaluation and treatment of respiratory impairment. Amyotroph Lateral Scler Other Motor Neuron Disord. 2002; 3(1):5-13
Lo Coco DL, Marchese S, Pesco MC, La Bella V, Piccoli F, Lo Coco A. Noninvasive positive-pressure ventilation in ALS: Predictors of tolerance and survival. Neurology 2006; 67: 761-5
Mackin GA. Optimizing care of patients with ALS. Steps to early detection and improved quality of life. Postgrad Med. 1999;105(4):143-6, 151-6.
Zuhal Karakurt. Evde mekanik ventilasyon. Yoğun Bakım Dergisi 2004;4: 145-50.