Pulmonary tuberculosis in infants less than one year old: implications for early diagnosis

Tüberküloz büyük çocuklarda iyi tanımlanmakla birlikte infantil tüberküloz çok iyi bilinmemektedir. Literatürde infantil tüberküloz ile ilgili çok az makale bulunmaktadır. Bu çalışmada Şubat 2007-Mayıs 2009 tarihleri arasındaki infantil tüberküloz olguları retrospektif olarak incelendi. Pulmoner tüberkülozlu 13 olgu saptandı. Hastaların en sık semptomları öksürük (%72.4), gece terlemesi (%35.7) ve ateşti (%21.4). Dört hastada hiçbir semptom yoktu. On üç hastanın 12’sinin fizik muayenesi normaldi. Tüm hastaların -akciğer grafisi normal olanların da- toraks bilgisayarlı tomografilerinde patoloji saptandı. Hastaların tümü antitüberküloz tedaviyi iyi tolere etti ve tedavi ile düzeldi. İnfantil tüberkülozun önlenmesi esas olarak aile içi tüberkülozlu olguların erken tespiti ve tedavisine dayanır. Bu çalışma yüksek şüphe, akciğer grafisi ve bilgisayarlı tomografinin doğru kullanımıyla infantil tüberkülozun erken tanısının mümkün olduğunu göstermiştir. Erken tanı ve tedavi hastalığın disseminasyonunu azaltabilir ve mortaliteyi düşürebilir; bu nedenle pediatristler infantil tüberküloz konusunda uyanık olmalıdır.

Bir yaş altı bebeklerde akciğer tüberkülozu: Erken tanının önemi

Tuberculosis in older children has been well described; however, its description in infants is very limited. There are a few studies of infants with tuberculosis in the literature. In this study from February 2007 to May 2009, cases of infantile tuberculosis investigated retrospectively. Thirteen patients with pulmonary tuberculosis detected. Mean age of the patients was 168.8 days. The most frequent symptoms were cough in 10 (72.4%) patients, night sweating in five (35.7%) and fever in three (21.4%). Four patients didn’t have any symptoms. Physical examinations were normal in 12 patients. Thorax computerized tomography studies of all of the patients were abnormal included the cases with normal chest radiographies. Antituberculosis treatment was well tolerated by all of the patients and all of them improved. Prevention of tuberculosis in infants rest upon the early detection and treatment of tuberculosis of the infant’s household members. This study demonstrates that with high index of suspicion and the correct use of chest radiographs and thorax computerized tomography, the disease diagnosed early in infants. Early diagnosis and treatment may prevent dissemination and may reduce mortality, so pediatrician should alert for tuberculosis in infants.

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  • 1. Jacobs RF, Starke JR. In: Long SS, Pickering LP, Prober CG (eds). Principles and Practice of Pediatric Infectious Diseases. Pennsylvania: Churchill Livingstone, 2003: 791-810.
  • 2. Lighter J, Rigaud M. Diagnosing childhood tuberculosis: traditional and innovative modalities. Curr Probl Pediatr Adolesc Health Care 2009; 39: 61-88.
  • 3. Country Profil. Turkey. Surveillance and epidemiology. http://apps.who.int/globalatlas/pr edefinedReports/ TB/PDF_Files/tur.pdf. Accessed September 18, 2009.
  • 4. Schaaf HS, Marais BJ, Whitelaw A, et al. Culture-confirmed childhood tuberculosis in Cape Town, South Africa: a review of 596 cases. BMC Infect Dis 2007; 7: 140.
  • 5. Cruz AT, Starke JR, Clinical manifestation of tuberculosis in children. Paediatr Rev 2007; 8: 107-17.
  • 6. Maltezou HC, Spyridis P, Kafetsiz DA. Tuberculosis during infancy. Int J Tuberc Lung Dis 2000; 4: 414-9.
  • 7. Newton SM, Brent AJ, Anderson S, et al. Paediatric tuberculosis. Lancet Infect Dis 2008; 8: 498-510.
  • 8. Schaaf HS, Gie RP, Beyers N, et al. Tuberculosis in infants less than 3 months of age. Arch Dis Child 1993; 69: 371-4.
  • 9. Ors F, Deniz O, Bozlar U, et al. High-resolution CT findings in patients with pulmonary tuberculosis: correlation with the degree of smear positivity. J Thorac Imaging 2007; 22: 154-9.
  • 10. Marais BJ. Tuberculosis in children. Pediatr Pulmonol 2008; 43: 322-9.
  • 11. Marais BJ, Gie RP, Hesseling AC, et al. A refined symptom-based approach to diagnose pulmonary tuberculosis in children. Pediatrics 2006; 118: 1350-9.
  • 12. Marais BJ, Pai M. New approaches and emerging technologies in the diagnosis of childhood tuberculosis. Paediatr Respir Rev 2007; 8: 124-33.
  • 13. Rigouts L. Clinical practice: diagnosis of childhood tuberculosis. Eur J Pediatr 2009; 168: 1285-90.
  • 14. Coulter JB. Diagnosis of pulmonary tuberculosis in young children. Ann Trop Paediatr 2008; 28: 3-12.
  • 15. Swingler GH, du Toit G, Andronikou S, et al. Diagnostic accuracy of chest radiography in detecting mediastinal lymphadenopathy in suspected pulmonary tuberculosis. Arch Dis Child 2005; 90: 1153-6.
  • 16. Kim WS, Moon WK, Kim IO, et al. Pulmonary tuberculosis in children: evaluation with CT. AJR Am J Roentgenol 1997; 168: 1005-9.
  • 17. Bosch-Marcet J, Serres-Créixams X, Zuasnabar-Cotro A, et al. Comparison of ultrasound with plain radiography and CT for the detection of mediastinal lymphadenopathy in children with tuberculosis. Pediatr Radiol 2004; 34: 895-900.
  • 18. Kim WS, Choi JI, Cheon JE, et al. Pulmonary tuberculosis in infants: radiographic and CT findings. AJR Am J Roentgenol 2006; 187: 1024-33.
  • 19. Okada F, Ando Y, Yoshitake S, et al. Clinical/pathologic correlations in 553 patients with primary centrilobular findings on high-resolution CT scan of the thorax. Chest 2007; 132: 1939-48.
  • 20. Donald PR, Schaaf HS. Old and new drugs for the treatment of tuberculosis in children. Paediatr Respir Rev 2007; 8: 134-41.
  • 21. World Health Organization: Guidance for national tuberculosis programmes on the management of tuberculosis in children. WHO, Geneva, WHO/HTM/TB/2006 371.
  • 22. Marais BJ, Gie RP, Hesseling AC, et al. Radiographic signs and symptoms in children treated for tuberculosis: possible implications for symptom-based screening in resource-limited settings. Pediatr Infect Dis J 2006; 25: 237-40.
Tüberküloz ve Toraks-Cover
  • ISSN: 0494-1373
  • Yayın Aralığı: 4
  • Başlangıç: 1951
  • Yayıncı: Tuba Yıldırım
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