Nursel DİKMEN, Nagihan BİLAL, Fulsen BOZKUŞ, Hüseyin ARPAĞ, Anıl SAMUR, Nurhan ATİLLA

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Obez olan ve olmayan osas’lı olgularda nötrofil lenfosit oranının önemi var mı?

Giriş: Obezite ve obezite ile ilgili hastalıklar, özellikle gelişmiş ülkelerde olmak üzere dünya çapında artmaktadır. Obstrüktif uyku apne sendromu (OUAS) ve obezite arasındaki ilişkinin bildirilmesine bağlı olarak OUAS insidansında bir artış görülmüştür. Obezite ile OUAS arasındaki etkileşimlerin yol açtığı sistemik inflamasyon, metabolik değişiklikler ve endokrin anomalilere bağlı olarak ateroskleroz ve kardiyovasküler hastalıklara yatkınlık vardır. Sistemik inflamasyon derecesini tahmin etmek için inflamatuar markerlar kullanılabilir; bunlar, metabolik riskler gibi gelecekteki advers etkiler için prognostik bir faktör olabilir. Yakın zamanda sistemik inflamasyonun bir göstergesi olarak kullanılmaya başlanan bir belirteç de nötrofil-lenfosit oranı (NLR)'dir. Amaç, obezite olan ve olmayan OUAS'lı hastalardaki sistemik inflamasyonun kolayca ölçülebilen bir parametresi olan NLR'yi değerlendirmektir. Materyal ve Metod: 155 hasta beden kitle indeksine göre dört farklı gruba ayrıldı. Her grup için lökosit, nötrofil, lenfosit, NLR değerleri ve antropometrik ölçümler karşılaştırıldı. Bulgular: Grup 4 (obez OUAS grubu)'ün NLR ve nötrofil sayıları grup 1, 2 ve 3’ ten istatistiksel olarak anlamlı derece daha yüksekti. Grup 4'ün (obez OUAS grubu) lenfosit sayıları tüm gruplar arasında en düşük olup, bu değerler grup 1 (kontrol grubu), 2 (normal ağırlık OSAS grubu) ve 3 (aşırı kilolu OSAS grubu) lenfosit sayılarına göre istatistiksel olarak anlamlı şekilde düşüktü (p< 0.001). Vücut kitle indeksi ile obez OUAS'lıların lenfosit sayıları arasında pozitif bir korelasyon vardı (r= 0.027, p= 353). Sonuç: Obezite derecesine göre NLR oranının arttığı ve bununla ilişkili olarakta inflamatuar yanıtın da arttığını görüldü. Obez OUAS'lılarda NLR bir inflamasyon belirteci olarak kullanılabilir ve bu kişiler için metabolik risklerin tahmininde faydalı olabilir.

Does the neutrophil-to-lymphocyte ratio have any importance between subjects with obstructive sleep apnea syndrome with obesity and without obesity?

Introduction: An increase in the incidence of OSAS (obstructive sleep apnoea syndrome) has been seen due to the reported association between OSAS and obesity. Subjects are predisposed to cardiovascular disease due to systemic inflammation caused by theinteractions between obesity and OSA. Inflammatory markers could be used to predict the degree of systemic inflammation, whichcould be a prognostic factor for future adverse events such as metabolic risks. One marker that has recently started being used as anindicator of systemic inflammation is neutrophil-to-lymphocyte ratio (NLR).Materials and Methods: The aim is to evaluate NLR, which is a easily measured parameter of systemic inflammation in OSAS subjectswith and without obesity. 155 subjects were assigned to four different groups according to their body mass indices. Comparisons ofwhite blood cell, neutrophil, lymphocyte, NLR values and anthropometric measurements were done for each group.Results: The NLR and neutrophil counts of group 4 were statistically significant and higher than those of groups 1, 2 and 3. Thelymphocyte counts of group 4 were the lowest amongst all groups,these values were lower than the lymphocyte counts of groups 1, 2 and 3 with statistically significant differences (p< 001). A positive correlation was found between the body mass index and lymphocyte count values of obese OSAS subjects (r= 0.027, p= 353).Conclusion: The NLR ratio was found to be increasing by obesity grade and reveals that the associated inflammatory response alsoincreases. The NLR ratio might be used as an inflammatory marker in obese OSAS subjects.
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Tüberküloz ve Toraks-Cover
  • ISSN: 0494-1373
  • Yayın Aralığı: 4
  • Başlangıç: 1951
  • Yayıncı: Tuba Yıldırım
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