Evrim Eylem AKPINAR

KOAH’ta göz ardı edilen bir komorbidite: Tiroid disfonksiyonu

Kronik obstrüktif akciğer hastalığı (KOAH)'nın morbidite ve mortalitesini etkileyen birçok sistemik etkisi vardır. KOAH’lı hastalarda KOAH olmayanlara göre daha sık görülen tiroid hastalıkları önemli klinik sonuçlarına rağmen yeterince önemsenmemektedir. Genel popülasyona benzer bir şekilde tiroid disfonksiyonları kadın KOAH’lılarda erkeklerden daha sık görülmektedir. Hem hipotiroidizm hem de hipertiroidizm KOAH’a eşlik edebilmektedir. KOAH’lı hastalarda sistemik inflamasyonun yanı sıra hipoksi, yaş, glukokortikoid kullanımı ve sigara içilmesi tiroid disfonksiyonu gelişiminde etkili olan bazı faktörlerdir. Bu derlemede KOAH’lı hastalarda az bilinen bir komorbidite olan tiroid disfonksiyonları, gelişim mekanizmaları ve klinik sonuçları gözden geçirilmiştir.

An underestimated comorbidity of COPD: Thyroid dysfunction

Chronic obstructive pulmonary disease (COPD) has many systemic effectsinfluencing morbidity and mortality of the disease. Thyroid diseases which aremore common in COPD patients than who do not have COPD are underestimated despite important clinical consequences. Similar to general population,thyroid dysfunctions are more common in females than males among COPDpatients. Both hypothyroidism and hyperthyroidism may be associated toCOPD. As well as systemic inflammation hypoxia, age, glucocorticoid use andsmoking are some of the effective factors on developing thyroid dysfunctionin COPD patients. In this article thyroid dysfunctions that are underrecognizedcomorbidities of COPD patients, their mechanisms of action and clinical outcomes were reviewed

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