Alp ŞENER, Melahat UZEL ŞENER, Ayperi ÖZTÜRK, Murat YILDIZ, Suna KAVURGACI, Figen ÖZTÜRK ERGÜR

Hastaneye yatan COVID-19 hastalarında mortalite belirteçlerinin değerlendirilmesi: Retrospektif kohort çalışması

Giriş: COVID-19 hastalığında prognoz tahmin ettirecek parametrelerin saptanması tedavi stratejisinin doğru belirlenmesini sağlamaktadır. Bu çalışmada mortaliteye etki eden klinik, radyolojik ve laboratuvar parametrelerinin belirlenmesi, risk faktörlerinin değerlendirilmesini amaçlanmıştır. Materyal ve Metod: Eylül 2020’de COVID-19 tanısı ile hastaneye yatırılan hastalar çalışmaya dahil edildi. Başvuru sırasındaki klinik özellikleri, laboratuvar parametreleri, radyolojik bulguları kaydedildi. Bu parametrelerin 30 günlük mortalite ile ilişkisi değerlendirildi. İstatistiksel analizler SPSS-for-Windows 16.0 Paket Programı ile yapıldı. Bulgular: Belirtilen sürede hastaneye yatan 360 hasta (228/132, K/E) çalışmaya alındı. Tüm hastalarda 30 günlük mortalite oranı 14,4% saptandı. Çoklu Lojistik regresyon analizinde yaş, kalp yetmezliği varlığı, başvuru oksijen satürasyonu, vücut sıcaklığının 38,2’den yüksek olması ve yüksek ferritin düzeyleri 30 günlük mortalite için bağımsız risk faktörleri olarak değerlendirildi. Sonuç: Klinik ve laboratuvar belirteçler ile mortalite arasındaki ilişki, COVID-19 salgını sırasında sağlık hizmetlerinin doğru yönlendirilmesi ve tedavi stratejisinin doğru belirlenmesi açısından çok önemlidir.

Evaluation of mortality predictors in hospitalized COVID-19 patients: Retrospective cohort study

Introduction: Evaluation of parameters that will predict prognosis in COVID19 disease ensures correct determination of treatment strategy. In this study, it was aimed to determine the clinical, radiological and laboratory parameters affecting mortality and to evaluate the risk factors. Materials and Methods: Patients hospitalized with the diagnosis of COVID-19 in September 2020 were included in the study. Clinical features, laboratory parameters, and radiological findings at admission were recorded. The relationship of these parameters with 30-day mortality was evaluated. Statistical analysis was performed with SPSS for Windows 16.0 Package Program. Results: Three hundred and sixty patients (female/male, n= 228/132) hospitalized in the specified period were included in the study. 30-day mortality rate was 14.4% in all patients. In multiple logistic regression analysis, age, presence of heart failure, admission oxygen saturation, body temperature higher than 38.2 and high ferritin levels were evaluated as independent risk factors for 30-day mortality. Conclusion: The relationship between clinical and laboratory markers and mortality is very important for the correct orientation of healthcare services and the correct determination of treatment strategy during the COVID-19 pandemic.

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