Efficacy of pulmonary rehabilitation on patients with non-cystic bronchiectasis according to disease severity

Efficacy of pulmonary rehabilitation on patients with non-cystic bronchiectasis according to disease severity Introduction: The European Respiratory Society guidelines support pulmonary rehabilitation (PR) in bronchiectasis through high-quality evidence. This study aimed to evaluate the efficacy of PR on bronchiectasis patients according to disease severity assessed by the Bronchiectasis Severity Index (BSI). Materials and Methods: This prospective study included patients with stable bronchiectasis. Demographic data of all patients were questioned. All patients underwent an 8-week PR program. The patients were grouped into three according to disease severity (mild, moderate and severe) based on their BSI scores. The following parameters were evaluated at baseline (pre-PR) and after PR (post-PR): pulmonary function test results, carbon monoxide diffusion capacity, body mass index, exercise capacity (6-minute walking test), quality of life (QoL; St. George’s Respiratory Questionnaire), and Hospital Anxiety and Depression scores. Results: The study included 69 patients (55 males; mean age, 62.6 ± 9 years). After PR, the patients were observed to have significantly improved QoL and exercise capacity (p< 0.05). According to BSI, 16 (23.2%), 29 (42.0%), and 24 (34.8%) patients had mild, moderate, and severe bronchiectasis, respectively. These patient groups significantly differed regarding age, exercise capacity, and QoL (p< 0.05). Comparing the change between post-PR and pre-PR values of the study parameters (∆ = post-PR value - pre-PR value), no significant differences were observed regarding the exercise capacity and QoL (p> 0.05) in the groups. Conclusion: PR increases exercise capacity and QoL in bronchiectasis patients, and its efficacy does not differ according to disease severity. Thus, appropriate bronchiectasis patients should be referred to PR program regardless of disease severity

___

1. Polverino E, Goeminne PC, McDonnell MJ, Aliberti S, Marshall SE, Loebinger MR, et al. European Respiratory Society guidelines for the management of adult bronchiectasis. Eur Respir J 2017; 50 (3): 1700629.

2. Chalmers JD, Aliberti S, Polverino E, Vendrell M, Crichton M, Loebinger M, et al. The EMBARC European Bronchiectasis Registry: protocol for an international observational study. ERJ Open Res 2016; 2 (1): 00081-2015.

3. Chalmers JD, Goeminne P, Aliberti S, McDonnell MJ, Lonni S, Davidson J, et al. The bronchiectasis severity index. An international derivation and validation study. Am J Respir Crit Care Med 2014; 189(5): 576-85.

4. Chalmers JD, Chotirmall SH. Bronchiectasis: new therapies and new perspectives. Lancet Respir Med 2018; 6(9): 715-26.

5. Lee AL, Button BM, Ellis S, Stirling R, Wilson JW, Holland AE, et al. Clinical determinants of the 6-Minute Walk Test in bronchiectasis. Respir Med 2009; 103(5): 780-5.

6. Spruit MA, Singh SJ, Garvey C, ZuWallack R, Nici L, Rochester C, et al; ATS/ERS Task Force on Pulmonary Rehabilitation. An official American Thoracic Society/ European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Am J Respir Crit Care Med 2013; 188(8): e13-64. Erratum in: Am J Respir Crit Care Med 2014; 189 (12): 1570.

7. ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med 2002; 166(1): 111-7.

8. Polatlı M, Yorgancıoğlu A, Aydemir Ö, Demirci NY, Kırkıl G, Naycı SA, et al. St. George solunum anketinin Türkçe geçerlilik ve güvenilirliği [Validity and reliability of Turkish version of St. George’s respiratory questionnaire]. Tuberk Toraks 2013; 61(2): 81-7.

9. Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand 1983; 67(6): 361-70.

10. Aydemir O, Guvenir T, Küey L, Kültür S. Validity and reliability of Turkish version of Hospital Anxiety and Depression Scale. Turk Psikiyatri Derg 1997: 8: 280-8. [Turkish].

11. Zanini A, Aiello M, Adamo D, Cherubino F, Zampogna E, Sotgiu G, et al. Effects of Pulmonary Rehabilitation in Patients with Non-Cystic Fibrosis Bronchiectasis: A Retrospective Analysis of Clinical and Functional Predictors of Efficacy. Respiration 2015; 89(6): 525-33.

12. Ong HK, Lee AL, Hill CJ, Holland AE, Denehy L. Effects of pulmonary rehabilitation in bronchiectasis: A retrospective study. Chron Respir Dis 2011; 8(1): 21-30.

13. Mandal P, Sidhu MK, Kope L, Pollock W, Stevenson LM, Pentland JL, et al. A pilot study of pulmonary rehabilitation and chest physiotherapy versus chest physiotherapy alone in bronchiectasis. Respir Med 2012; 106(12): 1647-54.

14. Chang AB, Bilton D. Exacerbations in cystic fibrosis: Noncystic fibrosis bronchiectasis. Thorax. 2008; 63(3): 269- 76.

15. Morrissey BM. Pathogenesis of bronchiectasis. Clin Chest Med 2007; 28(2): 289-96.

16. Finklea JD, Khan G, Thomas S, Song J, Myers D, Arroliga AC. Predictors of mortality in hospitalized patients with acute exacerbation of bronchiectasis. Respir Med 2010; 104(6): 816-21.

17. Martínez-García MA, Soler-Cataluña JJ, Perpiñá-Tordera M, Román-Sánchez P, Soriano J. Factors associated with lung function decline in adult patients with stable non-cystic fibrosis bronchiectasis. Chest 2007; 132(5): 1565-72.

18. Lee AL, Hill CJ, Cecins N, Jenkins S, McDonald CF, Burge AT, et al. The short and long term effects of exercise training in non-cystic fibrosis bronchiectasis--a randomised controlled trial. Respir Res 2014; 15(1): 44.

19. Lee AL, Hill CJ, McDonald CF, Holland AE. Pulmonary rehabilitation in individuals with non-cystic fibrosis bronchiectasis: A systematic review. Arch Phys Med Rehabil 2017; 98(4): 774-82.e1.

20. Burtin C, Hebestreit H. Rehabilitation in patients with chronic respiratory disease other than chronic obstructive pulmonary disease: exercise and physical activity interventions in cystic fibrosis and non-cystic fibrosis bronchiectasis. Respiration 2015; 89(3): 181-9.
Tüberküloz ve Toraks-Cover
  • ISSN: 0494-1373
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1951
  • Yayıncı: Tuba Yıldırım
Sayıdaki Diğer Makaleler

Relationship between 18F-FDG PET/CT radiometabolic markers and EGFR mutation, positive ALK Expression in patients with non-small cell lung cancer

Mine GAYAF, Nimet AKSEL, Ahmet Emin ERBAYCU, Hakan KOPORAL, Ceyda ANAR

Pulmonary fibrotic-like changes on follow-up chest CT exam in patients recovering from COVID-19 pneumonia

Ahmet VURAL, Ahmet KAHRAMAN

Efficacy of pulmonary rehabilitation on patients with non-cystic bronchiectasis according to disease severity

Sami DENİZ, Hülya DOĞAN ŞAHİN, Ahmet Emin ERBAYCU

Astımda uzun süreli makrolid tedavisi

İnsu YILMAZ, Gülden PAÇACI ÇETİN, Bahar ARSLAN

Current situation in ARDS in the light of recent studies: Classification, epidemiology and pharmacotherapeutics

Fatma YILDIRIM, İrem KARAMAN, Akın KAYA

Influenza viruses and SARS-CoV-2 in adult: ‘Similarities and differences’

Şerife TORUN, Berna BOTAN YILDIRIM, Çağrı KESİM, Aynur SÜNER, Özgür ÖZEN, Şule AKÇAY

Comparison of the effectiveness of high-flow and conventional nasal cannula oxygen therapy in pulmonary embolism patients with acute hypoxemic respiratory failure

Alperen AKSAKAL, Leyla SAĞLAM, Buğra KERGET, Elif YILMAZEL UÇAR

Diyaliz ve böbrek nakli hastalarında SARS-CoV-2 mRNA aşısı sonrası immunojenesite: Sistematik derleme

Mehmet KANBAY, Asiye KANBAY, Merve AKYOL, Enes ÇEVİK, Duygu UCKU, Cem TANRIÖVER, Barış AFŞAR, Adrian COVIC, Alberto ORTIZ, Carlo BASILE

Clinical characteristics of lung cancer patients with COVID-19: Retrospective case series

Yusuf KAHYA, Buse Mine KONUK, Cabir YÜKSEL, GÜLE ÇINAR, Kemal OSMAN MEMİKOĞLU

COVID-19’dan önce olsa idiopatik olarak tanımlanacak hayatı tehdit edici hemoptizi olgusu

Hakan EMMUNGİL, Celal KARLIKAYA, İlker YILMAM, Bilkay SEREZ KAYA, Osman KULA