Derya TATLISULUOĞLU, Eda DERLE, Ruhsen OCAL, Seda KİBAROGLU, Fatma Belgin ATAÇ, Ufuk CAN

Aurasız migrenlilerde tümör nekroz faktörü α-308 G/A polimorfizmi ve serum tümör nekroz faktörü α düzeyleri arasındaki ilişki

Amaç: Bu çalışmanın amacı, tümör nekroz faktör (TNF)-α 308 G/A genotipinin migren ile ilişkisini ve aurasız migrenlilerde serum TNF- α düzeyi üzerine etkisini araştırmaktır. Yöntem: Bu çalışmaya aurasız migren tanılı 70 hasta ile migreni olmayan 65 kişiden oluşan kontrol grubu dahil edildi. Hasta grubunda TNF-α seviyesi biri atak biri ataksız dönemde olmak üzere alınan iki ayrı kan örneğinden ayrı ayrı çalışılmış, TNF-α 308 G/A geno-tipi ise bir kez çalışılmıştır. Kontrol grubunda da TNF-α seviyesi ve TNF-α 308 G/A genotipi birer kez çalı-şılmıştır. Bulgular: Migren (n=70) grubunda ataklı ve ataksız dönemde TNF-α seviyesi sırasıyla 13.58±2.84 pg/mL ve 12.91±3.39 pg/mL idi. Bu fark istatistiksel olarak anlamlıydı (p=0.033). G/A genotipi olan migren hasta-larında (n=38) atak sırasında ortalama serum TNF-a seviyesi, 14.37±3.4 pg/mL ve A/A genotipi olanlarda (n=30) ise 12.79±1.54 pg/mL idi. İki grup arasındaki fark (p=0.034) istatiksel olarak anlamlıydı. Ayrıca genotip dağılımının migren gelişimi üzerindeki etkisi istatistiksel olarak anlamlı olarak bulundu (p=0.003). Sonuç: TNF-α 308 G/A polimorfizmi, Türkiye’deki migren hastaları ile ilişkilidir ve aurasız migrenli has-talarda TNF- α seviyesi ataklı dönem ile ataksız dö-nemle karşılaştırıldığında artmaktadır. TNF-α 308 G/A polimorfizmi ile serumdaki TNF-α seviyeleri arasın-daki ilişkinin belirlenmesi için daha fazla çalışmalar gerekir.

Anahtar Kelimeler:

TNF-α, migren, TNF-α 308 G/A polimorfizmi

The relationship between tumor necrosis factor α-308 G/A poly-morphism and serum tumor necrosis factor α levels in patients with migraine without aura

Objective: The aim of this study is to investigate the association of tumor necrosis factor (TNF) α-308 G/A genotype with migraine risk and the effect on serum TNF-α levels in patients with migraine without aura. Methods: A total number of 70 patients with the diag-nosis of migraine without aura and 65 control subjects were included in this study. TNF-α level was studied from two separate blood samples taken from the pa-tient group during an attack and attack-free period separately and TNF-α-308 G/A genotype was studied once while one blood sample was taken for studying the TNF-α-308 G/A and TNF-α level genotype from the control group. Results: The mean TNF-α level during an attack and attack-free periods were 13.58±2.84 pg/mL and 12.91±3.39 pg/mL, respectively in patients with mi-graine (n=70). This difference was statistically signifi-cant (p=0.033). The mean serum TNF-α level during an attack was 14.37±3.4 pg/mL in the migraine patients with G/A genotype (n= 38) and 12.79±1.54 pg/mL in those with A/A genotype (n=30); the difference be-tween the two groups was statistically significant (p=0.034). The effect of genotype distribution on mi-graine development was statistically significant (p=0.003). Conclusion: TNF-α-308 G/A polymorphism is related to migraine in Turkish patients and TNF-α level in-creases during an attack compared with attack-free periods in patients with migraine without aura. Further studies are required for determining the relationship between TNF-α308 G/A polymorphism and TNF-α levels in the serum.

Keywords:

TNF-α, migraine, TNF-α-308 G/A polymorphism,

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