Dilek BAYRAMGÜLER, Kürşat YILDIZ, Evren Odyakmaz DEMİRSOY, Cengiz ERÇİN, Rebiay KIRAN

Pseudoepitheliomatous hyperplasia in mycosis fungoides

Psödoepitelyamatöz hiperplazi (PEH) epidermis ve adneksiyal yapıların iyi diferansiye skuamöz hücreli karsinomu taklit eder tarzda, alt dermise doğru proliferasyonudur. Başlıca iyi huylu nadiren de kötü huylu birçok farklı tabloya eşlik edebilir. PEH'nin kutanöz lenfomalarla ilişkisi literatürde nadiren bildirilmiştir. Burada klinik olarak mikozis fungoidesin tümör evresiyle uyumlu olan vejetatif nodüllerin yanı sıra hastalığın tipik plak lezyonlarıyla başvuran 76 yaşındaki bir erkek hasta sunulmaktadır. Tümöral lezyonların histopatolojik incelemesinde tümöral lezyonların PEH'ye bağlı geliştiği saptandı. Takip sürecinde lenf nodu tutulumu tespit edildi. PEH ile ilişkili mikozis fungoides olgularının yakın takip edilmesi gerektiğini düşündük.

Mikozis fungoideste psödoepitelyamatöz hiperplazi

Pseudoepitheliomatous hyperplasia (PEH) is down-growth proliferation of the epidermis and of the adnexal structures into the dermis, mimicking a well-differentiated squamous cell carcinoma. It might be associated with many different conditions, mostly benign but rarely with some malignant conditions. Association of PEH with cutaneous lymphomas has occasionally been reported in the literature. Here, we report a 70-year-old man who presented with vegetative nodules clinically appearing as a tumor stage of mycosis fungoides,besides typical plaques of the disease. Histopathological examination of the tumor lesion revealed that the bulk of the tumor was due to PEH. During the follow-up period lymph node involvement was determined. We considered that mycosis fungoides cases associated with PEH should be followed up closely.

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