Cavidan ARAR, Gaye KAYA, Beyhan KARAMANLIOĞLU, Ayşin ALAGÖL, Ayça ÖZDEN, Zafer PAMUKÇU

Geriyatrik hastalarda sevofluran ve isofluranın derlenme kriterleri üzerine etkilerinin karşılaştırılması

Amaç: Bu çalışmada, geriyatrik hastalarda volatil anesteziklerden sevofluran ve isofluranın derlenme kriterleri üzerine etkileri karşılaştırıldı. Çalışma Planı: Elektif ürolojik ve jinekolojik cerrahi girişim planlanan ASA I-II grubundan 65 yaş ve üzeri 40 hasta rastgele eşit sayıda iki gruba ayrıldı. Tüm olguların premedikasyonu intramusküler 0.06 mgkg-1 midazolam, anestezi indüksiyonu intravenöz 1.5 mgkg-1 propofol, 0.6 mgkg-1 atrakuryum besilat ve 500 g alfentanil ile gerçekleştirildi. Anestezi idamesi grup I’de 1 MAC isofluran, grup II’de 1 MAC sevofluran ve gerektikçe intravenöz 0.1 mgkg-1 atrakurium ile sürdürüldü. Ameliyat sonunda her iki grupta da derlenme kriterleri olarak belirlenen spontan göz açma, ekstübasyon, sözel yanıt ve oryantasyon süreleri kaydedildi. Bulgular: Sevofluran grubunda, isofluran grubuna göre spontan göz açma (p=0.0002), ekstübasyon (p=0.0002), sözel yanıt (p=0.0001) ve oryantasyon (p=0.0001) süreleri anlamlı derecede kısa bulundu. Sonuç: Geriyatrik olgularda sevofluranın derlenme kriterleri açısından isoflurana göre daha avantajlı olduğu kanısına varıldı.

Anahtar Kelimeler:

İzofluran, Yaşlı, Anesteziden uyanma dönemi, Anestezikler, Ameliyat sonrası dönem

Comparison of recovery criteria following anaesthesia with sevoflurane and isoflurane in geriatric patients

Objectives: The aim of this study was to compare the effects of volatile anesthetics, sevoflurane and isoflurane, on recovery criteria in geriatric patients. Study Design: Forty ASA I-II patients at the age of 65 years or above, who were planned for elective urological or gynecological operation were randomized to two groups equal in number. Each group received 0.06 mgkg-1 intramuscular midazolam for premedication, and intravenous 1.5 mgkg-1 propofol, 0.6 mgkg-1 atracurium besylate, and 500 µg alfentanil for induction. Anesthesia was maintained with approximately 1 MAC isoflurane in group I, and 1 MAC sevoflurane in group II, and, when necessary, intravenous 0.1 mgkg-1 atracurium. Recovery criteria included spontaneous eye opening, extubation, verbal response, and orientation times at the end of operation. Results: Compared to the isoflurane group, durations of spontaneous eye opening (p=0.0002), extubation (p=0.0002), verbal response (p=0.0001), and orientation (p=0.0001) were significantly shorter in the sevoflurane group. Conclusion: We concluded that sevoflurane anesthesia is more advantegous over isoflurane in geriatric patients.

Keywords:

Isoflurane, Aged, Anesthesia Recovery Period, Anesthetics, Postoperative Period,

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