COŞKUN ÇELTİK, Yasemin KÜÇÜKUĞURLIOĞLU, Demet Benek BALCI, Naci ÖNER, Rıdvan DURAN, Serap KARASALİHOĞLU

Evaluation of clinical and laboratory features of Epstein-Barr virus-associated acute infectious mononucleosis in children

Amaç: Epstein-Barr virüsünden kaynaklanan enfeksiyöz mononukleozun değişik semptomları, ayırıcı tanıda hekimlerin aklını karıştırabilir. Bu çalışmanın amacı semptomatik çocuklarda bu hastalışın klinik ve laboratuvar bulgularının değerlendirilmesidir. Hastalar ve Yöntemler: Bu çalışma akut Epstein- Barr virüs eneksiyonu olan 52 olgu (31 erkek, 21 kız; ort. yaş 5.4±3.4; dağılım 1-13) üzerinde retrospektif olarak yürütüldü. Klinik ve laboratuvar bulgular, şikayetler başladıktan sonraki başvuru zamanı (≤5/>5 gün) ve yaş gruplarına (≤2/>2 yıl) göre değerlendirildi. Bulgular: Major semptomlar klasik triadda yer alan ateş, lenfadenopati, tonsillofarenjit idi. Ayrıca asit, artrit ve şiddetli abdominal ağrıyla başvuran atipik olgular da tanımlandı. Hiçbir olguda kötü bir prognoz gözlenmedi. En sık rastlanan laboratuvar bulgu lenfositozdu. Major semptomlar başvuru zamanı ≤5 gün olan grupta daha sık iken, atipik lenfositler başvuru zamanı >5 gün olan grupta daha yüksek bulundu. Bu tür farklılıklar yaş grupları arasında saptanmadı. Sonuç: Epstein-Barr virüsüne bağlı enfeksiyöz mononükleoz, çocuklarda iyi prognozlu bir hastalıktır. Hastalık özellikleri başvuru gününe göre değişkenlik gösterebilir, tanıda bu durum göz önüne alınmalıdır.

Anahtar Kelimeler:

Çocuk, Herpesvirüs 4, insan, Enfeksiyöz mononükleoz, Seyir, Geriyedönük çalışma, Epstein-barr virüs enfeksiyonları

Çocuklarda Epstein-Barr virüsüyle ilişkili akut enfeksiyöz mononükleozun klinik ve laboratuvar özelliklerinin değerlendirilmesi

Objectives: The various symptoms of infectious mononucleosis associated with Epstein-Barr virus may confuse physicians in differential diagnosis. The aim of this study is to evaluate the clinical and laboratory findings of this disease in symptomatic children. Patients and Methods: This study was retrospectively performed on 52 cases (31 boys, 21 girls; mean age 5.4±3.4 years; range 1 to 13 years) with acute Epstein-Barr virus infection. The clinical and laboratory findings were evaluated according to admission time after initial complaints (≤5/>5 days) and the age groups of the cases (≤2/>2 years). Results: The major symptoms were fever, lymphadenopathy and tonsillopharyngitis in the classical triad. Moreover, atypical cases who had ascites, arthritis and severe abdominal pain were defined. No case had a poor prognosis. The most frequent laboratory finding was lymphocytosis. While the major symptoms were more frequent in the group “admission time ≤ 5 days”, the count of atypical lymphocyte were higher in the group “admission time > 5 days”. However, these differences could not be defined between age groups. Conclusion: Infectious mononucleosis due to< Epstein-Barr virus is a disease with good prognosis in children. The features of the disease may vary according to admission time, and this fact should be taken into consideration in the diagnosis.

Keywords:

Child, Herpesvirus 4, Human, Infectious Mononucleosis, Prognosis, Retrospective Studies, Epstein-Barr Virus Infections,

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