Introduction: By the use of iodine-containing intravenous contrast agents, sialadenitis rarely occurs with a sudden expansion of the salivary glands. Its pathogenesis is uncertain, but it appears to be the result of an idiosyncratic reaction or accumulation of iodine in the ductal system of the salivary gland. In this article, we aimed to present a case of contrast-induced sialadenitis after an iodine-containing contrast agent. Case Presentation: A sixty-six-year-old male with a history of abdominal aortic aneurysm was referred for CT angiography. The patient had referred to emergency service with mildly tenderness, pain, and swelling in the bilateral submandibular region. Physical examination also revealed mildly enlarged bilateral submandibular glands, with no fever. There was no erythema, ulcer, and no symptom in both oral and oropharyngeal mucosa. The US performed bilateral diffuse homogeneous expansion of the submandibular salivary glands. In the light of clinical and radiological findings, contrast-induced non-suppurative sialadenitis was considered. Conclusion: Non-suppurative sialadenitis is a rare adverse effect of contrast material administration, which true incidence is unknown. Chronic kidney failure and repeated dose of contrast material are risk factors for this complication. We think that this adverse effect deserves more attention, and follow-up, and prevention for recurrence because its long-term importance is unknown yet.