Altay ATEŞPARE, Aslı BATUR ÇALIŞ, Öner ÇELİK, Neşe YENER, Çetin VURAL

Tiroidin eşzamanlı medüller ve papiller karsinomu

Papiller tiroid karsinomu PTK ve medüller tiroid karsinomunun MTK aynı tiroid bezinde simültane oluşumu nadir bir durumdur. Bu tümörler farklı hücrelerden köken alır; PTC foliküler hücrelerden kaynaklanırken MTC parafoliküler hücrelerden kaynaklanır. Bu nedenle, bu tümörlerin tedavisi de farklıdır. Bu yazıda tiroid bezinde MTK ve PTK’nın simültane oluşumuna dair iki nadir olgu tanımlandı

Anahtar Kelimeler:

Kanser, eşzamanlı, medüller, papiller, tiroid

Concurrent medullary and papillary carcinoma of thyroid

Simultaneous occurrence of papillary thyroid carcinoma PTC and medullary thyroid carcinoma MTC in the same thyroid gland is a rare condition. These tumors derive from different cells; PTC originates from follicular cells whereas MTC originates from parafollicular cells. Because of this, the treatment of these tumors also differs. This article describes two rare cases of the simultaneous occurrence of MTC and PTC in the thyroid gland.

Keywords:

Cancer, concurrent, medullary, papillary, thyroid,

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Lamberg BA, Reissel P, Stenman S, Koivuniemi A, Ekbolm M, Mäkinen J, et al. Concurrent medullary and papillary thyroid carcinoma in the same thyroid lobe and in siblings. Acta Med Scand 1981;209:421-4.
Biscolla RP, Ugolini C, Sculli M, Bottici V, Castagna MG, Romei C, et al. Medullary and papillary tumors are frequently associated in the same thyroid gland without evidence of reciprocal influence in their biologic behavior. Thyroid 2004;14:946-52.
Vural Ç, Koç AÖ, Çelikoyar MM. Meduller tiroit kanseri. Türkiye Klinikleri Kulak Burun Boğaz Dergisi, Tiroit Özel Sayısı 2007;3:35-40.
Machens A, Dralle H. Simultaneous medullary and papillary thyroid cancer: a novel entity? Ann Surg Oncol 2012;19:37-44.
Romei C, Fugazzola L, Puxeddu E, Frasca F, Viola D, Muzza M, et al. Modifications in the papillary thyroid cancer gene profile over the last 15 years. J Clin Endocrinol Metab 2012;97:1758-65.
Gul K, Ozdemir D, Ugras S, Inancli SS, Ersoy R, Cakir B. Coexistent familial nonmultiple endocrine neoplasia medullary thyroid carcinoma and papillary thyroid carcinoma associated with RET polymorphism. Am J Med Sci 2010;340:60-3.
Kim WG, Gong G, Kim EY, Kim TY, Hong SJ, Kim WB, et al. Concurrent occurrence of medullary thyroid carcinoma and papillary thyroid carcinoma in the same thyroid should be considered as coincidental. Clin Endocrinol (Oxf) 2010;72:256-63.