Cüneyt Orhan KARA, Neşe DEMİRKAN

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Tavşanda deneysel sinüzit modelleri üzerine bir inceleme

Deneysel hayvan modelleri, hastalıkların patogene- zini arafltırmak ve tedavi sonuçlarını incelemek için çok uygun araçlardır. Tavflan sinüslerinin büyüklü- ğü ve kolay ulaflılabilirliği, tavflanın sinüzit arafltır- malarında sık kullanılmasına yol açmıfltır. Mikrobi- yolojik ve histopatolojik özellikleri iyi tanımlanmıfl olan bu model, tıbbi ve cerrahi tedavi sonuçlarının incelenmesinde baflarıyla uygulanmaktadır. Bunun- la birlikte, insandaki sinüzit patogenezini daha iyi taklit edebilen bir tavflan modeli gelifltirebilmek için daha basit ve invaziv olmayan yöntemler arafltırıl- m a k t a d ı r. Bu yazıda, tavflan sinüzit modelinin tek- nik, cerrahi, mikrobiyolojik, histopatolojik, radyolojik özellikleri ve komplikasyonları üzerine sonbilgiler gözden geçirildi
Anahtar Kelimeler:

Hastalık modeli, hayvan, maksiller sinüs/patoloji/mikrobiyoloji, burun boflluğu, burun mukozası, tavflan, sinüzit/patoloji/mikrobiyoloji

A review on experimental sinusitis models in rabbits

Experimental animal models are instrumental to study the pathogenesis of diseases and to examine the results of treatment. The great size and ease of acces-sibility have made rabbit sinuses popular in the investigation of experimental sinusitis. Microbiologic, histopathologic, and radiologic aspects of this model have been well-described and the effects of medical and surgical treatments on sinusitis have been examined. Ongoing research may provide further data to find more simple and non-invasive methods to induce sinusitis in rabbits that may more closely simulate sinusitis pathogenesis in humans. This article reviews the most recent data on technical, surgical, microbiologic, histopathologic, and radiologic aspects, and complications of sinusitis models in rabbits.
Keywords:

Disease models, animal, maxillary sinüs/ pathology/microbiology, nasal cavity, nasal mucosa, rab­bits, sinusitis/pathology/microbiology,

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The Turkish Journal of Ear Nose and Throat-Cover
  • ISSN: 2602-4837
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1991
  • Yayıncı: İstanbul Üniversitesi
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Tavşanda deneysel sinüzit modelleri üzerine bir inceleme

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