Sinonazal inverted papillom ve ilişkili durumların pozitron emisyon tomografi ile değerlendirilmesi: Bir prospektif klinik çalışma

Amaç: Bu çalışmada inverted papillom İP ile nazal polip ve yassı hücreli karsinom YHK arasında florodeoksiglukoz tutulumu açısından fark olup olmadığı belirlendi.Hastalar ve Yöntemler: Eylül 2007 ile Mayıs 2014 yılları arasında, muayene ve paranazal sinüs tomografi taramalarında tek taraflı polipozis tespit edilen 27 hastanın 20 erkek, 7 kadın; ort. yaş 53.4 yıl; dağılım 18-74 yıl pozitron emisyon tomografi bilgisayarlı tomografi PET/BT görüntüleri elde edildi. Hastaların sekizinde nazal polip grup 1 , 10’unda İP grup 2 ve dokuzunda YHK grup 3 saptandı. Veriler Kruskal-Wallis ve Mann-Whitney U testleri ile karşılaştırıldı.Bulgular: Ortalama standardize edilmiş maksimum tutulum SUVmaks değerleri, grup 1’de 2.9; grup 2’de 7.8; grup 3’te 17.8 olarak bulundu. Grup 1 ve 2 p=0.016 , grup 1 ve 3 p=0.001 ve grup 2 ile 3 arasında p=0.01 SUVmaks değerleri arasında anlamlı bir fark bulundu.Sonuç: Bu çalışmanın sonuçlarına göre tek taraflı polipozis hastalarında PET/BT taraması nazal polibi İP ve YHK’den ayırt etmede değerlidir. Bununla birlikte, İP ve YHK ayrımının yapılmasında da yararlıdır. Yirmi yedi hastalık çalışmamıza göre, 6 ya da üzerinde SUVmax değeri nazal polip varlığının dışlanmasında da klinik olarak kullanılabilir [95% CI 5.93 to 13.39 , özgünlük %100]

Positron emission tomography evaluation of sinonasal inverted papilloma and related conditions: a prospective clinical study

Objectives: This study aims to determine whether there is a difference between inverted papilloma IP and nasal polyp, and squamous cell carcinoma SCC with regard to fluorodeoxyglucose uptake. Patients and Methods: Between September 2007 and May 2014, positron emission tomography computed tomography PET/CT images of 27 patients 20 males, 7 females; mean age 53.4 years; range 18 to 74 years , with unilateral polyposis diagnosed on examination and tomographic scans of paranasal sinus were obtained. Nasal polyps in eight of the patients group 1 , IP in 10 patients group 2 , and SCC in nine patients group 3 were found. The data were compared with Kruskal-Wallis and Mann-Whitney U tests. Results: The mean maximum standardized uptake SUVmax values were found to be 2.9 in the group 1; 7.8 in the group 2, and 17.8 in the group 3. There was significant difference in the SUVmax values between the group 1 and the group 2 p=0.016 , the group 1 and the group 3 p=0.001 , and the group 2 and the group 3 p=0.01 . Conclusion: According to the results of this study, PET/CT scan in the patients with unilateral polyposis is invaluable to distinguish nasal polyp from IP and SCC. It is also useful to recognize the distinctions between IP and SCC. In our study of 27 patients, a SUVmax of 6 or higher ruled out the presence of nasal polyp [95% CI 5.93 to 13.39 , specificity 100%] might also be clinically useful.

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