Merkel cell carcinoma of the oral cavity: A case report

Merkel cell carcinoma of the oral cavity: A case report

Merkel cell carcinoma (MCC) is a rare, but highly aggressive neuroendocrine neoplasm. It usually affects the head and neck regionof the skin exposed to ultraviolet radiation from the sun. Although rare, there are primary oral cavity cases reported in the literature.Herein, we present an 80-year-old male case with a mucosal MCC located in the oral cavity as evidenced by both morphological andimmunohistochemical findings.

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  • 1. Tang CK, Toker C. Trabecular carcinoma of the skin: an ultrastructural study. Cancer 1978;42:2311-21.
  • 2. Tang CK, Toker C. Trabecular carcinoma of the skin: further clinicopathologic and ultrastructural study. Mt Sinai J Med 1979;46:516-23.
  • 3. Mir R, Sciubba JJ, Bhuiya TA, Blomquist K, Zelig D, Friedman E. Merkel cell carcinoma arising in the oral mucosa. Oral Surg Oral Med Oral Pathol 1988;65:71-5.
  • 4. Islam MN, Chehal H, Smith MH, Islam S, Bhattacharyya I. Merkel cell carcinoma of the buccal mucosa and lower lip. Head Neck Pathol 2018;12:279-85.
  • 5. Feng H, Shuda M, Chang Y, Moore PS. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science 2008;319:1096-100.
  • 6. Chang Y, Moore PS. Merkel cell carcinoma: a virus-induced human cancer. Annu Rev Pathol 2012;7:123-44.
  • 7. Li M, Saghafi N, Freymiller E, Basile JR, Lin YL. Metastatic Merkel cell carcinoma of the oral cavity in a human immunodeficiency viruspositive patient and the detection of Merkel cell polyomavirus. Oral Surg Oral Med Oral Pathol Oral Radiol 2013;115:e66-71.
  • 8. Tanio S, Matsushita M, Kuwamoto S, Horie Y, Kodani I, Murakami I, et al. Low prevalence of Merkel cell polyomavirus with low viral loads in oral and maxillofacial tumours or tumour-like lesions from immunocompetent patients: Absence of Merkel cell polyomavirus-associated neoplasms. Mol Clin Oncol 2015;3:1301-6.
  • 9. Leech SN, Kolar AJ, Barrett PD, Sinclair SA, Leonard N. Merkel cell carcinoma can be distinguished from metastatic small cell carcinoma using antibodies to cytokeratin 20 and thyroid transcription factor 1. J Clin Pathol 2001;54:727-9.
  • 10. Zeng M, Yang SD, Zhang JL, Chen XM. Primary small cell neuroendocrine carcinoma of the oral cavity: A case report and review of the literature. Oncol Lett 2015;10:887-90.
  • 11. Hanly AJ, Elgart GW, Jorda M, Smith J, Nadji M. Analysis of thyroid transcription factor-1 and cytokeratin 20 separates merkel cell carcinoma from small cell carcinoma of lung. J Cutan Pathol 2000;27:118-20.
  • 12. Hendrikx SMGA, De Wilde PCM, Kaanders JHAM, Blokxc WAM, Poorter RL, Merkx MAW. Merkel cell carcinoma of the oral cavity: a case presentation and review of the literature. Oral Oncology Extra 2005;41:202-6.
The Turkish Journal of Ear Nose and Throat-Cover
  • ISSN: 2602-4837
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1991
  • Yayıncı: İstanbul Üniversitesi