İrfan BAYRAM, Serdar UĞRAŞ, Muzaffer KIRIŞ, Deniz REÇBER

Larenksin adenokarsinomu: Histokimyasal ve immünohistokimyasal değerlendirme ile birlikte olgu sunumu

Nadir görülen larengeal tümörlerin histolojik olarak farklı bir grubu olan adenokarsinomlar, tüm larenge- al karsinomların %1’inden azında görülür. Bir başka şekilde spesifiye edilmeyen nonspesifik larenks adenokarsinomu çok seyrek görülür ve malignensi derecesi yüksektir. Bu makalede 60 yaşında erkek hastadaki larenks adenokarsinomunu sunuldu. His- tolojik olarak tümör dokusu sadece adenokarsinom komponentiyle sınırlıydı. Histokimyasal olarak tümör hücrelerinde Alcian blue pH: 2.5 ve PAS ile boyan- ma izlendi ve arjentafin ile arjirofil granüller görülme- di. İmmünohistokimyasal olarak desmin, HMB45 ve NSE ile boyanma izlenmezken S-100 ve kromogra- nin ile fokal olarak ve sitokeratin ile diffüz olarak tü- mör hücrelerinin boyandığı görüldü

Anahtar Kelimeler:

Adenokarsinom/patoloji/cerrahi, immünohistokimya, larenks neoplazmları/patoloji/cerrahi, larenjektomi.

The adenocarcinoma of the larynx: case report with histochemical and immunohistochemical studies

Adenocarcinomas constitute a histologically diverse group of rare laryngeal neoplasms accounting in aggre- gate for less than 1% of ali laryngeal carcinomas.Adenocarcinoma of the larynx “not othervvise specified” NOS is a very uncommon neoplasia, but it shows a high degree of malignancy. We report a case of ade nocarcinoma “NOS” arising in the larynx of a 60 year- old man. Histologically, tumor tissue was composed of only adenocarcinoma component. Histochemically, the adenocarcinoma cells demonstrated Alcian blue pH: 2.5 and PAS reactivity; but did not include argentaffin and argyrophil granules. İmmunohistochemical studies revealed negative reactivity for desmin, HMB45 and NSE. S-100 and chromogranin was focally positive, cytokeratin was diffuse positive.

Keywords:

Adenocarcinoma/pathology/surgery, immunohistochemistry, laryngeal neoplasms/pathology/surgery, laryngectomy,

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