Amir MİNOVİ, Ahmet URAL, Chantal NOWARK, Marc PEARSON, Stefan DAZERT, Dominik BRORS

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Larenks karsinomu nedeniyle tek başına lazer mikrocerrahisi veya beraberinde adjuvan radyoterapi uygulanan olgularda uzun dönem yaşam kalitesi değerlendirmesi

Amaç: Larenks karsinomu nedeniyle sadece lazer mikrocerrahisi veya lazer mikrocerrahisi ile birlikte adjuvan radyoterapi uygulanan olguların uzun dönem yaşam kalitesi sonuçları değerlendirildi.Hastalar ve Yöntemler: Larenks karsinomu nedeniyle lazer mikrocerrahisi uygulanan 53 hasta ve lazer mikrocerrahisi ile birlikte adjuvan radyoterapi uygulanan 16 hasta çalışmaya katıldı. Yaşam kalitesinin değerlendirilmesinde genel duruma yönelik olarak EORTC QLQ-C30 ve baş-boyun bölgesine yönelik olarak EORTC QLQ-H&N35 formları kullanıldı. Ortalama takip süresi 59 ay dağılım 20-111 ay idi.Bulgular: Genel sağlık durumu bakımından adjuvan radyoterapi uygulanan hastaların daha kötü durumda oldukları saptandı. İlginç bir bulgu olarak, baş-boyun bölgesine özgü semptomlar bakımından iki grup arasında fark izlenmedi. Öksürük ve konuşma sorunları her iki grupta da göze çarpmaktaydı. Ayrıca, uzun dönem >5 yıl ve kısa dönem
Anahtar Kelimeler:

Larenks neoplazileri/cerrahi, lazer tedavisi/yöntem, yaşam kalitesi, anket, radyoterapi, adjuvan/yan etki

Long-term quality of life evaluation after laser microsurgery with or without adjuvant radiotherapy for laryngeal carcinoma

Objectives: We evaluated long-term quality of life of patients successfully treated with either laser-assisted microsurgery alone or combined with adjuvant radiotherapy for laryngeal carcinoma. Patients and Methods: The study included 53 patients who were treated by laser surgery and 16 patients who were treated by laser surgery combined with adjuvant radiotherapy. Quality of life was evaluated with two validated questionnaires: the global EORTC QLQ-C30 and the head and neck specific EORTC QLQ-H&N35. The mean follow-up was 59 months range 10 to 111 months . Results: Patients receiving adjuvant radiotherapy showed a significantly lower level of global health status. Surprisingly, the two treatment groups showed close similarities with respect to symptoms specific to the head and neck region. The most frequent complaints were coughing and speech problems in both groups. On the other hand, patients with a follow-up duration of more than or less than five years did not differ significantly with regard to the global health status. Conclusion: Adjuvant radiotherapy must be selectively utilized in patients treated with laser surgery for laryngeal carcinoma.
Keywords:

Laryngeal neoplasms/surgery, laser therapy/ methods, quality of life, questionnaires, radiotherapy, adjuvant/adverse effects,

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  • Ambrosch P. The role of laser microsurgery in the treatment of laryngeal cancer. Curr Opin Otolaryngol Head Neck Surg 2007;15:82-8.
  • Steiner W. Results of curative laser microsurgery of laryngeal carcinomas. Am J Otolaryngol 1993;14:116-21.
  • Ada M, Öz F, Toprak M, Öktem F, Kaytaz A, Yağız C ve ark. Laringeal mikrocerrahide CO2 lazer aritenoidek- tomi. Türk ORL Arşivi 1999;37:23-6.
  • Öz F, Oğuz F, Öktem F, Ada M, Toprak M. Selim larenks lezyonlarının cerrahi tedavisinde CO2 lazer ve soğuk cerrahi tekniğinin videolarengostroboskopik olarak karşılaştırılması. Türk ORL Arşivi 1999;37:27-31.
  • Ambrosch P, Rödel R, Kron M, Steiner W. Transoral laser microsurgery for cancer of the larynx. A retro- spective analysis of 657 patients. [Article in German] Onkologe 2001;7:505-12.
  • Eckel HE, Thumfart W, Jungehülsing M, Sittel C, Stennert E. Transoral laser surgery for early glottic carcinoma. Eur Arch Otorhinolaryngol 2000;257:221-6.
  • Moreau PR. Treatment of laryngeal carcinomas by laser endoscopic microsurgery. Laryngoscope 2000; 110:1000-6.
  • Loughran S, Calder N, MacGregor FB, Carding P, MacKenzie K. Quality of life and voice following endoscopic resection or radiotherapy for early glottic cancer. Clin Otolaryngol 2005;30:42-7.
  • Tas A, Yagiz R, Karasalihoglu AR, Koten M, Adali MK, Uzun C. Assessment of quality of life in patients with laryngeal cancer after surgical treatment. [Article in Turkish] Kulak Burun Bogaz Ihtis Derg 2004;12:84-90.
  • Müller R, Paneff J, Köllner V, Koch R. Quality of life of patients with laryngeal carcinoma: a post-treatment study. Eur Arch Otorhinolaryngol 2001;258:276-80.
  • Ohlwein S, Kruse E, Steiner W, Kiese-Himmel C. Voice function and quality of life-patients with laryngeal carcinoma following minimal-invasive laser surgery and function voice rehabilitation. [Article in German] Laryngorhinootologie 2005;84:253-60.
  • Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a qual- ity-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 1993;85:365-76.
  • Bjordal K, Kaasa S. Psychometric validation of the EORTC Core Quality of Life Questionnaire, 30-item version and a diagnosis-specific module for head and neck cancer patients. Acta Oncol 1992;31:311-21.
  • Bjordal K, Ahlner-Elmqvist M, Tollesson E, Jensen AB, Razavi D, Maher EJ, et al. Development of a European Organization for Research and Treatment of Cancer (EORTC) questionnaire module to be used in quality of life assessments in head and neck cancer patients. EORTC Quality of Life Study Group. Acta Oncol 1994; 33:879-85.
  • Goudakos JK, Markou K, Nikolaou A, Themelis C, Vital V. Management of the clinically negative neck (N0) of supraglottic laryngeal carcinoma: A systematic review. Eur J Surg Oncol 2008 May 9. [Epub]
  • Gallo A, de Vincentiis M, Manciocco V, Simonelli M, Fiorella ML, Shah JP. CO2 laser cordectomy for early- stage glottic carcinoma: a long-term follow-up of 156 cases. Laryngoscope 2002;112:370-4.
  • Hammerlid E, Mercke C, Sullivan M, Westin T. A prospective quality of life study of patients with laryn- geal carcinoma by tumor stage and different radiation therapy schedules. Laryngoscope 1998;108:747-59.
  • Olthoff A, Steuer-Vogt MK, Licht K, Sauer-Goenen M, Werner C, Ambrosch P. Quality of life after treatment for laryngeal carcinomas. ORL J Otorhinolaryngol Relat Spec 2006;68:253-8.
  • Stoeckli SJ, Guidicelli M, Schneider A, Huber A, Schmid S. Quality of life after treatment for early laryngeal car- cinoma. Eur Arch Otorhinolaryngol 2001;258:96-9.
  • Bindewald J, Oeken J, Wollbrueck D, Wulke C, Dietz A, Herrmann E, et al. Quality of life correlates after surgery for laryngeal carcinoma. Laryngoscope 2007; 117:1770-6.
  • List MA, Ritter-Sterr CA, Baker TM, Colangelo LA, Matz G, Pauloski BR, et al. Longitudinal assessment of quality of life in laryngeal cancer patients. Head Neck 1996;18:1-10.
The Turkish Journal of Ear Nose and Throat-Cover
  • ISSN: 2602-4837
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1991
  • Yayıncı: İstanbul Üniversitesi
Arşiv
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