Larenks kanseri cerrahisinde boyun metastazının sağkalıma etkisi
Amaç: Larenks kanseri nedeniyle ameliyat edilen hastagrubunda boyun metastazının sağkalım oranına etkisi değerlendirildi.Hastalar ve Yöntemler: 1995-1999 yılları arasında ameliyat edilen 256 hasta retrospektif olarak incelendi. Takipedilebilen 186 hasta %72; 185 erkek, 1 kadın; ort. yafl57.5 primer tümör tipi, yerleflimi, boyun metastazı, uygulanan cerrahi yöntem ve sağkalım oranları açısından değerlendirildi. Kümülatif yaflam süresinin hesaplanmasındaKaplan-Meier yöntemi, sonuçların karflılafltırılmasında iselog rank testi kullanıldı. Yaflayan ve yaflamayan hastalarda boyun metastazı ve kapsül dıflı yayılım oranlarının değerlendirilmesinde ki-kare testi kullanıldı. Hastaların izlemsüresi en az iki yıl ort. 41.2 ay idi.Bulgular: Yirmi dokuz hasta lokorejyonel nüks veya uzakmetastaz, altı hasta ise diğer nedenlerden yaflamını yitirdi.Ameliyat sonrası ortalama yaflam süresi 69 ay bulundu. Busüre boyun metastazı olmayanlarda 75 ay, olanlarda 54 ay idi log rank testi 27.96, p
Anahtar Kelimeler:
Bafl-boyun neoplazmları, larenjeal neoplazmlar/cerrahi, lenf nodu eksizyonu, lenf nodu/cerrahi, lenfatik metastaz, boyun/cerrahi, boyun diseksiyonu/yöntem, neoplazm evrelemesi, prognoz, sağkalım oranı
The effect of neck metastasis on survival following surgery for laryngeal cancer
Objectives: We evaluated the effect of neck metastasis on the survival rate of patients who undervvent surgery for laryngeal cancer.Patients and Methods: A total of 256 patients who had undergone surgery betvveen 1995 and 1999 were retrospectively revievved. Of these, 186 patients 72%; 185 males, 1 female; mean age 57.5 years who were accessible for follow-up were evaluated with respect to the localization and type of the pri- mary tumor, neck metastasis, surgical procedures, and the sur vival. Survival rates were determined by the Kaplan-Meier method and compared by the log-rank test. The rates of neck metastasis and extracapsularspread in survivors and non-sur- vivors were compared with the use of the chi-square test. The minimum follow-up period was two years mean 41.2 months .Results: Twenty nine patients died from locoregional recurrences or distant metastasis and six patients died from other causes. The cumulative survival period was 69 months 75 months and 54 months with or vvithout neck metastasis, respectively; log rank test 27.96, p<0.0001 .The rates of neck metastasis and extracapsular spread in sur vivors 22%, 33/151; 7%, 10/151 and non-survivors 69%, 20/29; 59%, 17/29 were significantly different p<0.001 .Conclusion: Neck metastasis and cervical recurrence were found as the most important factors affecting the results of laryngeal cancer surgery.
Keywords:
Head and neck neoplasms, laryngeal neoplasms/ surgery, lymph node excision, lymph nodes/surgery, lymphatic metas tasis, neck/surgery, neck dissection/methods, neoplasm staging, prognosis, survival rate,
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- ISSN: 2602-4837
- Yayın Aralığı: Yılda 4 Sayı
- Başlangıç: 1991
- Yayıncı: İstanbul Üniversitesi
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