Burun boşluğunda gangliogliom: Olgu sunumu

Gangliogliomlar hem astrositleri hem sinir ele- manlarını içeren tümörlerdir. Santral sinir sistemi ve omuriliğin her yerinde oluşabilir ancak nadir görülürler. Nazal glial heterotopi nazal gliom ola- rak da bilinmektedir geniş yaş grubunda görülen gelişimsel anomalilerdir. Gangliogliomlar nazal glial heterotopi olarak karşımıza çıkabilir ve burun kitlesi varlığında sinir kaynaklı tümörler mutlaka önemsenmelidir. Bu makalede sağ burun boş- luğuna yerleşen gangliogliom olgusu sunuldu. Kitle endoskopik yaklaşımla tam olarak çıkarıldı. Gangliogliom nazal glial heterotopi zemininde gelişmişti. Bilgilerimize göre burun boşluğundan kaynaklanan gangliogliom literatürde daha önce bildirilmemiştir

Ganglioglioma in the nasal cavity: a case report

Ganglioglioma is a tumor containing both astrocytic and neuronal components. It may occur any where in the central nervous system and spinal cord but is only encountered rarely. Nasal glial heterotopia also known as “nasal glioma” , is a rare developmental abnormality seen in a wide age group. Gangliogliomas may also manifest as a nasal glial heterotopia, and neurogenic tumors should be considered in the presence of a nasal mass. In this article, we present a case of ganglioglioma located in the right-nasal cavity. The mass was excised totally through an endoscopic approach. The ganglioglioma developed on a nasal glial heterotopia base. To our knowledge, a ganglioglioma arising from the nasal cavity has not been described previously in the literature.

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  • Penner CR, Thompson L. Nasal glial heterotopia: a clinicopathologic and immunophenotypic analysis of 10 cases with a review of the literature. Ann Diagn Pathol 2003;7:354-9.
  • Clarós P, Bandos R, Clarós A Jr, Gilea I, Clarós A, Real M. Nasal gliomas: main features, management and report of five cases. Int J Pediatr Otorhinolaryngol 1998;46:15-20.
  • Celik F, Kandemir B, Bilal S. Cerebellar ganglioglioma. Turkiye Klinikleri J Med Res 1988;6:195-8.
  • Ma KH, Cheung KL. Nasal glioma. Hong Kong Med J 2006;12:477-9.
  • Niedzielska G, Niedzielski A, Kotowski M. Nasal ganglioglioma-difficulties in radiological imaging. Int J Pediatr Otorhinolaryngol 2008;72:285-7.
  • Rubinstein LJ, Herman MM. A light- and electron- microscopic study of a temporal-lobe ganglioglioma. J Neurol Sci 1972;16:27-48.
  • Sikorska B, Papierz W, Zakrzewki K, Fiks T, Polis L, Liberski PP. Ultrastructural heterogeneity of ganglio- gliomas. Ultrastruct Pathol 2007;31:9-14.
  • Hakim R, Loeffler JS, Anthony DC, Black PM. Gangliogliomas in adults. Cancer 1997;79:127-31.
  • Miller DC, Lang FF, Epstein FJ. Central nervous sys- tem gangliogliomas. Part 1: Pathology. J Neurosurg 1993;79:859-66.
  • Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, et al. The 2007 WHO classifica- tion of tumours of the central nervous system. Acta Neuropathol 2007;114:97-109.
  • Bowles AP Jr, Pantazis CG, Allen MB Jr, Martinez J, Allsbrook WC Jr. Ganglioglioma, a malignant tumor? Correlation with flow deoxyribonucleic acid cytomet- ric analysis. Neurosurgery 1988;23:376-81.