Zeynep Güneş Özünal, Selçuk Şen, Ali Yağız Üresin, Iliriana Alloqi Tahirbegolli, Mehmet Baykal, Belen Ateş, Bernard Tahirbegolli, Yiğit Kılıç

The drug adherence and lifestyle factors that contribute to blood pressure control among hypertensive patients

Objectives: To investigate drug adherence and lifestyle behaviors affecting the blood pressure (BP) controlamong hypertensive patients that have uncontrolled and controlled BP.Methods: Seventy-eight uncontrolled BP and 98 controlled BP hypertensive patients matched on age, gender,time since hypertension diagnosis and the number of antihypertensive drugs used were investigated using astandardized questionnaire to evaluate lifestyle behaviors, drug adherence, the use of complementary andalternative medicine, and health related quality of life. Drug-drug interactions were evaluated with an electronicdrug reference software.Results: Not taking therapy when feeling better was observed significantly more frequently in the uncontrolledhypertensive group (OR: 0.297, %95 CI: 0.115-0.770). Uncontrolled BP hypertensive patients live morefrequently in extended family settings (p = 0.043), they sleep less controlled BP hypertensive patients (OR:0.749, %95 CI: 0.605-0.929). The groups did not differ statistically in terms of Complementary and AlternativeMedicine (CAM) use (p = 0.795) and informing doctors about the use of CAMs (p = 0.910). The EuroQolfive-dimensional 3 level (EQ5D3L) questionnaire Visual Analogue Scale (VAS) score was significantly higherin the control group (p = 0.011). In both groups over 70% of patients should be monitored for therapy due todrug interactions evaluation.Conclusions: Our study shows that increasing the drug adherence and sleeping hours and living in the nuclearfamily is associated with improvement in blood pressure control and health related quality of life. Acomprehensive approach and good patient-physician communication and trust are essential for well-managedhypertension.

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