Borderline Brenner tumor with a concomitant mucinous tumor of the ovary: a case report

Borderline Brenner tumor with a concomitant mucinous tumor of the ovary: a case report

Brenner tumors (BTs) are rare ovarian tumors which are a part of the epithelial stromal tumor group of ovarianneoplasms. Most of the BTs are benign and usually asymptomatic. BTs stand for the 1.4-2.5% of ovariantumors. Of the BTs, not more than 2% exhibit characteristics of borderline (or malignant) BTs. Borderline BTsare usually bigger than benign BTs and individuals typically represent with symptoms related with a unilateralovarian mass. BTs are often related with mucinous cystadenomas or seldom cystadenocarcinomas. We presenta case of borderline BT associated with a concomitant mucinous ovarian tumor

___

  • [1] Brenner F. Das Oophoroma Folliculare. Frankfurt Z Pathol 1907;1:150-71.
  • [2] Roma AA, Masand RP. Ovarian Brenner tumors and Walthard nests: a histologic and immunohistochemical study. Hum Pathol 2014;45:2417-22.
  • [3] Lee KR, Tavassoli FA, Prat J. Surface epithelial-stromal tumors. In: Tavassoli FA, Devilee P (eds). Pathology and genetics of tumors of the breast and female genital organs. World Health Organization (WHO) Classification of Tumors, International Agency for Research on Cancer (IARC) Press, Lyon, 2003, pp. 140-3.
  • [4] Nomura K, Aizawa S. A histogenetic consideration of ovarian mucinous tumors based on an analysis of lesions associated with teratomas or Brenner tumors. Pathol Intern 1997;47:862-5.
  • [5] Roth LM. The Brenner tumor and the Walthard cell nest: an electron microscopic study. Lab Invest 1974;31;15-23.
  • [6] Liao XY, Xue WC, Shen DH, Ngan HY, Siu MK, Cheung AN. p63 expression in ovarian tumors: a marker for Brenner tumors but not transitional cell carcinomas. Histopathology 2007;51:477-83.
  • [7] Murat A, Ozdemir H, Yildirim H, Arslan A, Ersoy F, Ozercan R. Bilateral malignant Brenner tumor of the ovary. J Womens Imaging 2005;7:126-30.
  • [8] Hermanns B, Faridi A, Rath W, Fuzesi L, Schroder W. Differential diagnosis, prognostic factors, and clinical treatment of proliferative Brenner tumor of the ovary. Ultrastruct Pathol 2000;24:191-6.
  • [9] Scully RE, Young RH, Clement PB. Tumors of the ovary, maldeveloped gonads, fallopian tube and broad ligaments. Armed Forces Institute of Pathology, Washington, pp 153-63, 1998.
  • [10] Daraï E, Fauvet R, Uzan C, Gouy S, Duvillard P, Morice P. Fertility and borderline ovarian tumor: a systematic review of conservative management, risk of relapse and alternative options. Hum Reprod Update 2013;19:151-66.