Ayfer GÖZÜ PİRİNÇÇİOĞLU, Mehmet TÜRE, Hasan BALIK, Sercan YÜCEL YANMAZ, Alper AKIN, Seçkin İLTER

A rare complication related to H1N1 infection: Dilated cardiomyopathy

The symptoms and findings of influenza A (H1N1) resemble the symptoms and findings of seasonal influenza and it generally emerges as an upper respiratory tract disease. Although the majority of patients with the influenza A virus recover spontaneously without complications, there have been occasional reports of myopericarditis. However, the most frequent complications have been reported as viral pneumonia and more rarely dilated cardiomyopathy. In this paper, we report a 4-month-old infant, who admitted with shortness of breath, cough, tachycardia and respiratory problems and was diagnosed as having developed dilated cardiomyopathy associated with H1N1.

PDF

___

[1] Jain R, Goldman RD. Novel influenza A (H1N1): clinical presentation, diagnosis, and management. Pediatr Emerg Care 2009; 25:791-6.
[2] Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team, Dawood FS, Jain S, Finelli L, Shaw MW, Lindstrom S, Garten RJ, et al. Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med2009;360:2605-15.
[3] Kasper EK, Agema WRP, Hutchins GM, Deckers JW, Hare JM, Baughman KL. The causes of dilated cardiomyopathy: a clinicopathologic review of 673 consecutive patients. J Am Coll Cardiol 1994;23:586-90.
[4] Venugopalan P, Agarwal AK, Worthing A. Chronic cardiac failure in children due to dilated cardiyomyopathy: diagnostic approach, pathophsiology and management. Eur J Pediatr. 2000;159:803-10.
[5] Nolte KB, Alakija P, Oty G, Shaw MW, Subbarao K, Guarner J, et al. Influenza A virus infection complicated by fatal myocarditis. Am J Forensic Med Pathol 2000;21:375-9.
[6] Park MK. Pediatric cardiology for practitioners. 5th ed. Philadelphia: Mosby Elsevier, 2008:360-7.
[7] Towbin JA. Myocarditis. In: Allen HD, Driscoll DJ, Shaddy RE, Feltes TF (eds). Moss and Adam's heart disease in infants, children and adolescent. 7th ed. Philedelphia: Lippincott Williams&Wilkins, 2008:1207-25.
[8] Jain R, Goldman RD. Novel influenza A (H1N1): clinical presentation, diagnosis, and management. Pediatr Emerg Care 2009;25:791-6.
[9] Wang S, Le TQ, Kurihara N, Chida J, Cisse Y, Yano M, et al. Influenza virus- cytokine-protease cycle in the pathogenesis of vascular hyperpermeability in severe influenza. J Infect Dis 2010;202:991-1001.
[10] Martin SS, Hollingsworth CL, Norfolk SG, Wolfe CR, Hollingsworth JW. Reversible cardiac dysfunction associated with pandemic 2009 influenza A(H1N1). Chest 2010;137:1195-7.
[11] Kaiser L, Wat C, Mills T, Mahoney P, Ward P, Hayden F. Impact of oseltamivir treatment on influenza-related lower respiratory tract complications and hospitalizations. Arch Intern Med 2003;163:1667-72.