Graham Little-Piccardi-Lassueur syndrome in a male patient: a case report

Graham Little-Piccardi-Lassueur syndrome is a type of lichen planopilaris characterized by the triad of patchy cicatricial alopecia of the scalp, non-cicatricial alopecia of the axilla and pubis, and follicular spinous papules on the body, scalp or both. This rare syndrome primarily affects middle-aged postmenopausal women with only three male cases being reported in literature. Herein we report a 53-year-old man who is fourth male patient diagnosed with Graham Little-Piccardi-Lassueur syndrome up to now. 

___

  • 1. Odom RB, James WD, Berger TG, editors. Andrews’ Diseases of the skin. Lichen planus and reletad conditions. 9th ed. Philadelphia: WB Saunders Company, 2000: pp. 274-5.
  • 2. Assouly P, Reygagne P. Lichen planopilaris: update on diagnosis and treatment. Semin Cutan Med Surg 2009;28:3-10.
  • 3. Graham-Little EG. Folliculitis decalvans et atrophicans. Br J Dermatol 1915;27:183-5.
  • 4. Srivastata M, Mikkilineni R, Konstadt J. Lassueur-Graham Little-Piccardi syndrome. Dermatol Online J 2007;13:12.
  • 5. Pai VV, Kikkeri NN, Sori T, Dinesh US. Graham Little-Picardi-Lassueur syndrome: an unusual variant of follicular lichen planus. Int J Trichology 2011;3:28-30.
  • 6. Laszlo FG. Graham Little-Picardi-Lassueur syndrome: a case report and review of the syndrome in men. Int J Dermatol 2014;53:1019-22.
  • 7. Teherney G, Nenoff P. Antigen mimicry followed by epitope spreading: a pathogenetic trigger for the clinical morphology of lichen planus and its transition to Graham Lassueur Piccardi Little syndrome and keratosis lichenoides chronic - Medical hypotesis or reality? Ann Bras Dermatol 2009;84:682-8.
  • 8. Rodriguez-Bayona B, Ruchaud S, Rodriguez C, Linares M, Astola A, Ortiz M, et al. Autoantibodies against the chromosomal passenger protein INCENP found in a patient with Graham Little-Picardi-Lassueur syndrome. J Autoimmune Dis 2007;4:1.
  • 9. Viglizzo G, Verrini A, Rongioletti F. Familial Lassueur-Graham Little-Piccardi syndrome. Dermatology 2004;208:142-4.
  • 10. Bardazzi F, Landi C, Orlandi C, Neri I, Varotti C. Graham Little-Piccardi-Lassueur syndrome following HBV vaccination. Acta Derm Venereol 1999;79:93.
  • 11. Vega Gutiérrez J, Miranda-Romero A, Pérez Milán F, Martínez García G. Graham Little-Piccardi-Lassueur syndrome associated with androgen insensitivity syndrome (testicular feminization). J Eur Acad Dermatol Venereol 2004;18:463-6.
  • 12. Graham Little-Picardi-Lassueur syndrome in a patient with androgen insensitivity syndrome. Int J Dermatol 2016;55:211-2.
  • 13. Ghislain PD, Van Eeckhout P, Ghislain E. Lassueur-Graham Little-Piccardi syndrome: a 20-year follox-up. Dermatology 2003;206:391-2.
  • 14. Elder DE, Elenitsas R, Johnson BL, Murthy GF, editors. Lever’s Histopathology of skin. Non infectious eythematous papular and squamous disease. 9th ed. Philadelphia: Lippincott William, 2005: pp. 179-214.
  • 15. Hixon C, Blattner CM, Hurd D. Graham-Little-Piccardi-Lassueur syndrome: a case report. JAOCD 2015;33:36-7.