KEMAL KÜRŞAT BOZKURT, Şirin BAŞPINAR, Raşit AKDENİZ, Sema BARCAN, Alim KOŞAR

Testis tümörleri: 5 yıllık olgu serisi

Giriş: Testis tümörleri erkeklerdeki malign tümörlerin %1-2sini oluşturmaktadır. Sıklıkla genç erkeklerde görülmekte olup dördüncü dekatta pik yapmaktadır. En sık görülen histolojik tip germ hücreli tümörlerdir. Bu çalışmada arşiv taraması yaparak bölümümüzde tanısı konan testis tümörü olgularının retrospektif olarak incelenmesi amaçlanmıştır. Gereç ve Yöntem: Çalışmamızda 2007 2012 yılları arasında Süleyman Demirel Üniversitesi Tıp Fakültesi Tıbbi Patoloji Anabilim Dalına histopatolojik inceleme için gönderilen 83 orşiektomi olgusuna ait patoloji raporları retrospektif olarak incelendi. Tümör tanısı alanlar seçilerek 2004 Dünya Sağlık Örgütü sınıflamasına göre sınıflandırıldı. Bulgular: Çalışmamızın sonucunda arşivimizde 2007-2012 yılları arasında tanı almış 45 adet testis tümörü tespit edilmiştir. Kırk beş tümörlü orşiektomi olgusunun 16sı (%35,6) klasik seminom, 3ü (%6,7) spermatositik seminom, 1i (%2,2) sinsityotrofoblastik hücreli seminom, 1i (%2,2) embriyonal karsinom, 17si (%37,8) mikst germ hücreli tümör, 6sı (%13,3) lenfoma ve 1i (%2,2) intratübüler germ hücreli neoplazi idi. Germ hücreli tümörler tüm testis tümörlerinin %86,7sini oluştururken, germ hücreli tümörlerin de %51,3ünü seminomların oluşturduğu görülmüştür. Sonuç: Serimizde yer alan testis tümörlerinin çoğunluğunu oluşturan germ hücreli tümörler içerisinde en sık seminomlar ve mikst germ hücreli tümörler izlenmiştir.

Testicular tumors: cases of a 5-year-serial

Background: Testicular tumors constitute 1-2% of malignancies in males. It is usually seen in young patients and its incidence increases in the 4th decade. Germ cell tumors are the most common histologic subtype. Our aim is to evaluate the testicular tumor cases, which were diagnosed in our department, retrospectively. Materials and Method: Pathology reports of 83 orchiectomy patients, which were diagnosed at the department of pathology in Süleyman Demirel University between 2007 and 2012, were evaluated, retrospectively. Tumoral cases were selected and classified according to the 2004 World Health Organization classification system. Results: A total of 45 testicular tumors were found in our pathology archive diagnosed between 2007 and 2012. Of the 45 tumoral cases 16 (35.6%) were classical seminoma, 3 (6.7%) were spermatocytic seminoma, 1 (2.2%) was seminoma with syncytiotrophoblastic cells, 1 (2.2%) was embryonal carcinoma, 17 (37.8%) were mixed germ cell tumors, 6 (13.3%) were lymphoma and 1 (2.2%) was intratubular germ cell neoplasia. Germ cell tumors constituted 86.7% of all testicular tumors, and 51.3% of them were seminomas. Conclusion: Germ cell tumors, which constituted the majority of testicular tumors in our series, included mostly seminomas and mixed germ cell tumors.

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1. Yörükoğlu K. Testis tümörlerinde prognozu belirleyen histopatolojik parametreler. Üroonkoloji Bülteni 2011;3:91-94.
2. Yalçınkaya U, Çalışır B, Uğraş N, ve ark. Testis tümörleri: 30 yıllık arşiv tarama sonuçları. Türk Patoloji Dergisi 2008;24(2):100-106.
3. Deotra A, Mathur DR, Vyas MC. A 18 years study of testicular tumours in Jodhpur, Western Rajasthan. Postgrad Med J 1994;40:68-70.
4. Khan O, Protheroe A. Testis cancer. Postgrad Med J 2007;83:624-632.
5. Bahrami A, Ro JY, Ayala AG. An overview of testicular germ cell tumors. Arch Pathol Lab Med 2006;131:1267-1280.
6. Che M, Tamboli P, Ro JY, et al. Bilateral testicular germ cell tumors twenty-year experience at M.D. Anderson Cancer Center. Cancer 2002;95:1228- 1233.
7. Akdogan B, Divrik RT, Tombul T, ve ark. Bilateral testicular germ cell tumors in Turkey: Increase in incidence in last decade and evaluation of risk factors in 30 patients. J Urol 2007;178:129-133.
8. Sesterhenn IA, Davis CJ. Pathology of germ cell tumors of the testis. Cancer Control 2004;11:374-387.
9. Eble JN, Sauter G, Epstein JI, et al. WHO Classification of Tumours. Pathology and Genetics of Tumors of the Urinary System and Male Genital Organs. IARC Press, Lyon, 2004:217-278.
10. Ferlay J, Bray F, Pisani P, et al. Cancer Incidence, mortality and prevelance worldwide. Version 1.0. IARC Cancer Base No. 5 Lyon:IARC Pres;2001.
11. Cheville JC. Classification and pathology of testicular germ cell and sex cord-stromal tumors. Urol Clin North Am 1999;26:595-609.
12. Walschaerts M, Muller A, Auger J, Bujan L, Guerin JF, Lannou DL, et al. Environmental, occupational and familial risks for testicular cancer: a hospital based case control study. Int J Androl 2007;30:222-229.
13. Coffin CM, Ewing S, Dehner LP. Frequency of ıntratubular germ cell neoplasia with invasive testicular germ cell tumors. Arch Pathol Lab Med 1985;109(6):555-559.
14. Manivel JC, Simonton S, Wold LE, et al. Absence of intratubular germ cell neoplasia in testicular yolk sac tumors in children. Arch Pathol Lab Med 1988;112:641-645.
15. Soosay GN, Bobrow L, Happerfield L, et al. Morphology and immunohistochemistry of carcinoma in situ adjacent to testicular germ cell tumors in adults and children: implicationshistogenesis. Histopathology 1991;19:537-544.
16. Albers P, MillerGA, OraziA, et al.Immunohistochemical assessment of tumor proliferation and volumeembryonal carcinoma identify patients with clinical stage A nonseminomatous testicular germ cell tumor at low risk for occult metastasis. Cancer 1995;75:844- 850.
17. Sturgeon JF, Jewett MA, Alison RE, et al. Surveillance after orchidectomy for patients with clinical stage I nonseminomatous testis tumors. J Clin Oncol. 1992;10:564-568.
18. Moul JW, McCarthy WF, Fernandez EB, etPercentage of embryonal carcinoma and vascular invasion predicts pathological stage in clinical stage I nonseminomatous testicular cancer. Cancer Res 1994;54:362-364.
19. de Riese WT, Albers P, Walker EB, et al. Predictive parameters of biologic behavior of early stage nonseminomatous testicular germ cell tumors. Cancer 1994;74:1335-1341.
20. Castedo SM, de Jong B, Oosterhuis JW, etChromosomal changes in human primary testicular nonseminomatous germ cell tumors. Cancer Res 1989;49:5696-5701.