Role of Tenascin-C in the differential diagnosis of small round blue cell tumors
Giriş: Bu çalışma; küçük yuvarlak mavi hücreli tümörlerde, serum tenascin-C düzeylerinin teşhis, tedavi ve takiplerdeki yerinin değerlendirilmesi amacıyla planlanmıştır. Gereç ve yöntem: Bu prospektif çalışmaya; 40 hasta ve kontrol grubu olarak 30 sağlıklı çocuk alındı. Hastalardan; tanı anında, tedavinin 3. ve 6. aylarında ve tedavi bittikten sonraki 3. ayda toplam dört defa, kontrol grubundan ise; bir defa serum örneği alınarak tenascin-C düzeyleri ölçüldü. Bulgular: Tüm hasta grubunun her dört ölçüm değeri de kontrol grubuna göre anlamlı derecede yüksekti (sırasıyla; p=0,013, p=0,009, p=0,011 ve p=0,015). Tüm hasta grubu alt gruplarına ayrılarak karşılaştırıldığında ise; sadece Wilms tümörü grubunun, ilk ölçüm değeri, kontrol grubuna göre anlamlı derecede yüksekti (p=0,026). Sonuç: Daha geniş hasta gruplarının katılımıyla yapılacak çalışmalara ihtiyaç olmakla beraber tenascin-C, Wilms tümörü grubunda olduğu gibi, bazı spesifik tümörlerin ayırıcı tanısında yol gösterici olabilir
Küçük yuvarlak mavi hücreli tümörlerin ayırıcı tanısında Tenascin-C'nin rolü
Objective: The aim of this study was to evaluate the significance of serum tenascin-C levels in the diagnosis, treatment, and monitoring of small round blue cell tumors. Materials and methods: Forty patients and 30 healthy children (control group) were included in this prospective study. Serum tenascin-C levels were measured from blood drawn at the time of diagnosis, at the 3rd and 6th months of treatment, and at 3 months following the completion of treatment. While serum tenascin-C levels were measured a total of 4 times in the patient group, they were measured just once in the control group. Results: Each of the four measured serum tenascin-C levels in the patient group was significantly higher than that of the control group (p=0,013, p=0,009, p=0,011 and p=0,015, respectively). However, when the patient group was categorized into subgroups, only those with Wilms tumor had a significantly higher serum tenascin-C level at the time of diagnosis than did the control group (p=0,026). Conclusion: While larger, more thorough studies are needed, our data suggest that tenascin-C may be useful in the differential diagnosis of certain specific tumors, such as the Wilms tumor
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- ISSN: 1300-7416
- Yayın Aralığı: Yılda 4 Sayı
- Başlangıç: 1994
- Yayıncı: SDÜ Basımevi / Isparta
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