PULMONER TROMBOEMBOLİ ŞÜPHESİNDE BT ANJİOGRAFİNİN VERİMLİLİĞİ VE PULMONER TROMBOEMBOLİ DIŞI RADYOLOJİK BULGULARIN ANALİZİ
Amaç Bu çalışmada amacımız pulmoner tromboemboli (PTE) şüphesiyle pulmoner BT anjiografi yapılan has talarda PTE pozitiflik oranını araştırmaktı. Ayrıca BT anjiografide saptanan alternatif tanıların sıklığını ve alternatif tanıların saptanmasında akciğer grafisinin rolünü belirlemekti. Gereç ve Yöntem Çalışmaya Ocak 2018- Mayıs 2018 tarihleri arasında acil servise başvuran ve PTE şüphesiyle pulmoner BT anjiografi yapılan hastalar dahil edildi. Radyolojik ra por bazında PTE negatif, PTE pozitif ve şüpheli olmak üzere hastalar üç gruba ayrıldı. PTE negatif grupta BT anjiografi incelemeleri alternatif tanılar yönünden iki radyolog tarafından gözden geçirildi. Alternatif ta nılar konsolidasyon, kitle ve amfizem gibi hastaların klinik ve semptomlarını açıklayan bulgular olarak ta nımlandı. Akciğer grafileri alternatif tanıların saptana bilirliği yönünden değerlendirildi. Başvuru anındaki semptomlar, klinik bulgular ve laboratuar bulguları kaydedildi. Bulgular Ocak 2018-Mayıs 2018 tarihleri arasında toplam 683 hastaya PTE şüphesiyle pulmoner BT anjiografi ya pılmıştı. Hastaların %6,4’ünde PTE pozitifti. PTE saptanmayan hastaların %65’inde klinik bulgular ve semptomları açıklayabilecek alternatif tanılar mev cuttu. En sık alternatif tanılar konsolidasyon, atelek tazi, amfizem ve bronşektaziydi. Bu alternatif tanıla rın %72’si hastaların akciğer grafilerinde de izlendi. Hastaların %15’inde semptomlarla ilişkisiz insidental bulgular saptandı. Sonuç Çalışmamızın sonucunda PTE şüphesiyle uygulanan pulmoner BT anjiografi incelemelerinde alternatif ta nıların PTE tanısından çok daha yüksek bir oranda saptandığını ve bu alternatif tanıların büyük çoğun luğunun ise BT’ye gerek kalmadan akciğer grafisi ile tespit edilebileceğini ortaya koyduk.
DIAGNOSTIC YIELD OF CT ANGIOGRAPHY AND ANALYSIS OF ALTERNATIVE RADIOLOGIC FINDINGS IN PATIENTS WITH SUSPECTED PULMONARY EMBOLISM
Objective The aim of this study was to assess diagnostic yield of pulmonary CT angiography and analyze alternative diagnoses in patients who underwent CT angiography with suspected pulmonary thromboembolism (PTE). It was also to determine the role of chest X-ray in the detection of alternative diagnoses. Materials and Methods Patients who underwent pulmonary CT angiography with suspicion PTE between January 2018-May 2018 were included in this study. On the basis of radiologi cal report, patients were divided into three groups as PTE negative, PTE positive and suspicious. Pulmo nary CT angiography images in the PTE negative group were reviewed by two radiologists for alternati ve diagnoses. Alternative diagnoses were defined as findings related to the clinical and symptoms of pa tients such as consolidation, tumor, and emphysema. Chest X-rays were evaluated for the detectability of alternative diagnoses. Symptoms, clinical, and labo ratory findings were recorded. Results A total of 683 patients underwent pulmonary CT angi ography. PTE was detected 6,4% of our patients. Of the patients without PTE, 65% had alternative diagno ses based on imaging. The most common alternative diagnoses were consolidation, atelectasis, emphyse ma, and bronchiectasis. 72% of these alternative di agnoses were also observed in patients' chest X-rays. Incidental findings unrelated to symptoms were dete cted in 15% of the patients. Conclusion As a result of our study, we revealed that alternative diagnoses in patients with suspected PTE were de tected at a much higher rate than PTE in pulmonary CT angiography, and the majority of these alternative diagnoses could be detected by chest X-ray without the need for CT.
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- 1. Stein PD, Fowler SE, Goodman LR, Gottschalk A, Hales CA, Hull RD, et al. Multidetector computed tomography for acute pulmonary embolism. N Engl J Med. 2006;354(22):2317-27.
- 2. Niemann T, Zbinden I, Roser HW, Bremerich J, Remy-Jardin M, Bongartz G. Computed tomography for pulmonary embolism: assessment of a 1-year cohort and estimated cancer risk associated with diagnostic irradiation. Acta Radiol. 2013;54(7):778- 84.
- 3. Mitchell AM, Jones AE, Tumlin JA, Kline JA. Prospective study of the incidence of contrast-induced nephropathy among patients evaluated for pulmonary embolism by contrast-enhanced computed tomography. Acad Emerg Med. 2012;19(6):618-25.
- 4. Stein PD, Woodard PK, Weg JG, Wakefield TW, Tapson VF, Sostman HD, et al. Diagnostic pathways in acute pulmonary embolism: recommendations of the PIOPED II investigators. Am J Med. 2006;119(12):1048-55.
- 5. Kindermann DR, McCarthy ML, Ding R, Frohna WJ, Hansen J, Maloy K, et al. Emergency department variation in utilization and diagnostic yield of advanced radiography in diagnosis of pulmonary embolus. J Emerg Med. 2014;46(6):791-9.
- 6. Chen YA, Gray BG, Bandiera G, MacKinnon D, Deva DP. Variation in the utilization and positivity rates of CT pulmonary angiography among emergency physicians at a tertiary academic emergency department. Emerg Radiol. 2015;22(3):221-9.
- 7. Venkatesh AK, Agha L, Abaluck J, Rothenberg C, Kabrhel C, Raja AS. Trends and variation in the utilization and diagnostic yield of chest imaging for medicare patients with suspected pulmonary embolism in the emergency department. AJR Am J Roentgenol. 2018;210(3):572-7.
- 8. Sharma S, Lucas CD. Increasing use of CTPA for the investigation of suspected pulmonary embolism. Postgrad Med. 2017;129(2):193-7.
- 9. Costa AF, Basseri H, Sheikh A, Stiell I, Dennie C. The yield of CT pulmonary angiograms to exclude acute pulmonary embolism. Emerg Radiol. 2014;21(2):133-41.
- 10. Costantino MM, Randall G, Gosselin M, Brandt M, Spinning K, Vegas CD. CT angiography in the evaluation of acute pulmonary embolus. AJR Am J Roentgenol. 2008;191(2):471-4.
- 11. Shahriar Z, Stephan R, Shweta M, Arun S, Mathew T, Brijal P, et al. Could the number of CT angiograms be reduced in emergency department patients suspected of pulmonary embolism? World J Emerg Med. 2012;3(3):172-6.
- 12. Mountain D, Keijzers G, Chu K, Joseph A, Read C, Blecher G, et al. RESPECT-ED: Rates of pulmonary emboli (PE) and sub-segmental PE with modern computed tomographic pulmonary angiograms in emergency departments: a multi-center observational study finds significant yield variation, uncorrelated with use or small PE rates. PLoS ONE. 2016;11(12): e0166483. 13. Van Es J, Douma RA, Schreuder SM, Middeldorp S, Kamphuisen PW, Gerdes VEA, et al. Clinical impact of findings supporting an alternative diagnosis on CT pulmonary angiography in patients with suspected pulmonary embolism. Chest. 2013;144(6):1893-9.
- 14. Anjum O, Bleeker H, Ohle R. Computed tomography for suspected pulmonary embolism results in a large number of non-significant incidental findings and follow-up investigations. Emerg Radiol. 2019;26:29-35.
- 15. Richardson S, Cohen S, Khan S, Zhang M, Qiu G, Oppenheim MI, et al. Higher imaging yield when clinical decision support is used. J Am Coll Radiol. 2020;17(4):496-503.
- 16. Ozakin E, Kaya FB, Acar N, Cevik AA. An analysis of patients that underwent computed tomography pulmonary angiography with the prediagnosis of pulmonary embolism in the emergency department. ScientificWorldJournal. 2014;2014:470358.
- 17. Ferreira EV, Gazzana MB, Sarmento MB, Guazzelli PA, Hoffmeister MC, Guerra VA, et al. Alternative diagnoses based on CT angiography of the chest in patients with suspected pulmonary thromboembolism. J Bras Pneumol. 2016;42(1):35-41.
- 18. Hall W, Truitt S, Scheunemann L. The prevalence of clinically relevant incidental findings on chest computed tomographic angiograms ordered to diagnose pulmonary embolism. Arch Intern Med. 2009;169(21):1961-5.