OXIDATIVE IMBALANCE IN AUTOIMMUNE LIVER DISEASE: EVALUATION OF OXIDANT-ANTIOXIDANT STATUS AND ISCHEMIA-MODIFIED ALBUMIN

ObjectiveCurrent study evaluated the utility of total antioxidantstatus (TAS), oxidative stress index (OSI), total oxidant status (TOS), ischemia-modified albumin (IMA),and ischemia-modified albumin ratio (IMAR) as markers in autoimmune liver disease (AILD).Material and MethodsThe study included a total of 66 AILD patients, 22 withautoimmune hepatitis (AIH), 32 with primary biliarycholangitis (PBC), and 12 with AIH/PBC overlap syndrome, and 49 healthy controls. Serum TAS, TOS,and IMA levels were analyzed. OSI was calculated asTOS/TAS and IMAR was derived from IMA and Alb.ResultsSerum TAS, OSI, TOS, IMA, and IMAR values werefound to be significantly higher in the AILD group compared to controls (p=0.004,

OTOİMMÜN KARACİĞER HASTALIĞINDA OKSİDATİF DENGESİZLİK: OKSİDAN-ANTİOKSİDAN DURUMUN VE İSKEMİ MODİFİYE ALBÜMİNİN DEĞERLENDİRİLMESİ

Amaç Bu çalışmada, otoimmün karaciğer hastalığında (AILD) belirteç olarak total antioksidan durum (TAS), oksidatif stres indeksi (OSI), total oksidan durum (TOS), iskemi modifiye albumin (IMA) ve iskemi modifiye albumin oranının (IMAR) yararı değerlendirildi. Gereç ve Yöntem Çalışma, 22'si otoimmün hepatit (AIH), 32'si primer biliyer kolanjit (PBC) ve 12'si AIH/PBC örtüşme sendromu olan toplam 66 AILD hastası ve 49 sağlıklı kontrol içermekteydi. Serum TAS, TOS ve IMA düzeyleri analiz edildi. OSI, TOS/TAS olarak hesaplandı ve IMAR, IMA ve Alb'den türetildi. Bulgular Serum TAS, TOS, OSI, IMA ve IMAR değerleri AILD grubunda kontrollere göre anlamlı olarak daha yüksekti (sırasıyla p=0.004,

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Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi-Cover
  • ISSN: 1300-7416
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1994
  • Yayıncı: SDÜ Basımevi / Isparta
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