Kas iskelet sistem ağrısı ile vitamin D düzeyleri arasındaki ilişkinin araştırılması

Son zamanlarda yapılan çalışmalar düşük D vitamini düzeyleri ile nonspesifik kas iskelet sistemi semptomları arasında ilişki olduğunu birdirilmektedir. Bu çalışmanın amacı kas iskelet sistem ağrısı olan premenopozal kadınlarda vitamin D.nin etkisini araştırmaktır. Çalışmaya kas iskelet sistem ağrısı olan 68 premenopozal kadın alındı. Hastalar normal ve düşük D vitamini düzeyleri olanlar olarak 2 gruba ayrıldı. Ağrı skoru, uyku kalitesi, Beck depresyon skoru, hassas nokta sayısı, serum parathormon, alkalen fosfataz, kalsiyum ve fosfor düzeyleri açısından gruplar arasında anlamlı farklılık bulamadık. Kas iskelet sistem ağrısında D vitaminin rolünün belirlenmesi amacıyla daha ileri çalışmalara ihtiyaç vardır.

Investigation of the relation to musculoskeletal pain and vitamin D levels

Recent studies reported that low vitamin D levels are related to nonspesific musculoskeletal symptoms. The aim of this study was to investigate the effect of vitamin D levels in premenopousal women with musculoskeletal pain. The study group consists of 68 premenouposal women with musculoskeletal pain. Patients were divided in two groups as low and normal vitamin D levels. We did not found any differences of pain score, sleep quality, Beck depression score, number of tender points and, serum parathormon, alkaline phosphatase, calcium and phosphorus levels between the groups. Further studies are needed to investigate the role of vitamin D in patients with musculoskeletal pain.

PDF

___

1. Shihadeh Y. Güneşe maruz kalma şekillerinin D vitamini üertimindeki rolü istanbul-1998 (Uzmanlıktezi)
2. McKenna MJ. Differences in vitamin D status between countries inyoung adults and elderly. Am J Med 1992; 7:69-77.
3. Haddad JG. Vitamin D-Solar rays, the milky way or both? N Engl JMed 1992; 18:1213-5.
4. Matsuoka LYı Ide Lı Wortsman J, MacLaughlin JAı HoliekMF. Sunscreens suppress eutaneous vitamin D3 synthesis. J Clin Endoerinol Metab 1987; 6:1165-8.
5. Holick MF. Too little vitamin D in premenopausal women: why should we care?. Am J Clin Nutr 2002;76:3 4
6. Reginato AJ, Falasca GF, Pappu R, McKnight B, Agha A Musculoskeletal manifestation of osteomalacia: report of 26 cases and literature review. Semin Artritis Rheum 1999;28:287-304
7. Glerup H, Mikkelsen K, Poulsen L. Commonly recommended daily intake of vitamin D is not sufficient if sunlight exposure is limited. J Intern Med 2000;66:419-24.
8. Chapuy MC, Preziosi P, Maamer M, Arnaud S, Galan P, Hercberg S, Meunier PJ. Prevalence of vitamin D insufficiency in an adult normal population. Osteoporos Int 1997;7:439-443
9. Mishal AA. Effects of different dress styles on vitamin D levels in healthy young Jordanian women. Osteoporos Int 2001;12:931-5
10. Scharla SH. Prevalence of Subclinical Vitamin D Deficiency in Different European Countries. Osteoporos Int 1998;8:7-12
11. Carnevale V, Modoni S, Pileri M, Di Giorgio A, Chiodini I, Minisola S, Vieth R, Scillitani A.. Longitudinal Evaluation of Vitamin D Status in Healthy Subjects from Southern Italy: Seasonal and Gender Differences. Osteoporos Int 2001;12:1026-30
12. Heath KM, Elovic EP. Vitamin D deficiency: implications in the rehabilitation setting. Am J Phys Med Rehabil 2006; 85:916-23.
13. Plotnikoff GA, Quigley JM. Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain. Mayo Clin Proc. 2003;78:1463-70.
14. Mascarenhas R, Mobarhan S. Hypovitaminosis D- induced Pain. Nutrition Reviews, 2004;62:354-9
15. Akkuş S, Tamer M.N, Yorgancigil H. A case of osteomalacia mimicking ankylosing spondylitis Rheumatol Int 2001;20:239-42
16. de Torrente de Jara G, Pecoud A, Favrat B. Musculoskeletal pain in female asylium seekers and hypovitaminosis D3. BMJ 2004;329:156-7.
17. Block SR. Vitamin D deficiency is not associated with nonspesific musculoskeletal pain syndromes including fibromyalgia. Mayo Clin Proc 2004;79:1585-6.
18. Helliwell PS, Ibrahim GH, Karim Z, Sokoll K, Jhonson H. Unexplained musculoskeletal pain in people of South Asian ethnic group referred to rheumatology clinic-relationship to biochemical osteomalacia, persistence over time and response to treatment with calcium and vitamin D. Clin Exp Rheumatol 2006;24:424-7.
19. Calvo MS, Whiting SJ. Prevalence of vitamin D insufficiency in Canada and the United States: importance to health status and efficacy of current food fortification and dietary supplement use. NutrRev. 2003;61:107-13.
20. Thomas MK, Lloyd-Jones DM, Thadhani RI, et al.Hypovitaminosis D in medical inpatients. N EnglJ Med. 1998;338:777-83.
21. Malabanan A, Veronikis IE, Holick MF. Redefining vitamin D insufficiency. Lancet 1998;351:805-6.
22. Holick MF. Vitamin D Deficiency: What a pain it is?. Mayo Clin Proc 2003;78:1457-9.
23. Shaunak S, Ang L, Maxwell JD. Osteomalacia presenting aspathological fracture during pregnancy in Asian women of high social class. Br Med J 1985; 16:1215.
24. Korszun A, et al. Melatonin levels in women with FMS and CFS. J Rheumatol 1999; 2 6(12): 2675-80