D vitamininin immün sistem, deri ve kanser ile ili?kisi

Ynsanlarda D vitamini ihtiyacynyn yakla?yk % 95i güne? y?ynlarynyn etkisiyle deride sentezlenmektedir. Böbrekdy?y dokularda da 1-alfa hidroksilaz enzimi aracyly?yyla aktif vitamin D sentezi gerçekle?mektedir. D vitaminininreseptör düzeyindeki etkisi aktif vitamin D sayesinde olur. Otuzdan fazla dokuda vitamin D reseptörlerigösterilmi?tir. Vitamin Dnin iskelet sistemi dy?yndaki etkileri 3 ana ba?lyk altynda toplanmaktadyr: Hormonsekresyonunun düzenlenmesi, immün fonksiyonlaryn düzenlenmesi, hücre proliferasyon ve farklyla?masynyndüzenlenmesi. Ymmün sistem, cilt hastalyklary ve kanser vitamin D ile ili?kisi en çok ara?tyrylan konulararasyndadyr.

The relation of vitamin D with immune system, skin and cancer.

The relation of vitamin D with immune system, skin and cancer.In humans, approximately 95% of the total requirement for vitamin D is synthesized in the skin by the effectsof sunlight. The active vitamin D synthesis from 25 (OH) D takes place via the 1-alpha hydroxylase enzymeboth in renal and non-renal tissues. The effect of vitamin D on the receptor level is through active vitaminD. Vitamin D receptors are shown in more than 30 tissues. Non-classical effects of vitamin D are groupedunder three main headings: Regulation of hormone secretion, regulation of immune function, regulation ofcell proliferation and differentiation. The relationship immune system, skin diseases cancer and vitamin Dis the most widely researched topics.

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