NURHAN GÜMRAL, SADETTİN ÇALIŞKAN, MEHMET AKDOĞAN, M. Fehmi ÖZGÜNER, Ahmet AKKAYA, Serpil Şen ÖZBAŞ, AHMET KOYU

Bronşial astımlı hastalarda lateralite ile antioksidanlar arasındaki ilişkilerin araştırılması

Bu çalışma, bronşial astımlı hastalarda ve sağlıklı kişilerde lateralite ile antioksidanlar arasındaki ilişkilerin araştırılması amacıyla yapıldı. Bronşial astımlı 30 hasta ve 30 sağlıklı birey olmak üzere 60 olguda, araştırma için ilgili etik kuruldan izin alınarak eritrositer süperoksit dismutaz, glutatyon peroksidaz ve serum melatonin düzeylerinin tayinleri yapıldı. Ayrıca herbir olguya el tercihi anketinin modifiye şekli Geschwind Skoru uygulandı. Bronşial astımlı hastalarda sağ el tercihi yüksek olup; eritrositer süperoksit dismutaz, serum melatonin düzeyleri kontrol grubuna göre anlamlı olarak düşük bulundu. Eritrositer glutatyon peroksidaz düzeyleri bronşial astımlı hastalarda düşük olmakla beraber iki grup arasında anlamlı bir fark saptanamadı. Lateralite ile süperoksit dismutaz düzeyi arasında negatif bir korelasyon gözlendi. Çalışmamızda, bronşial astım hastalığı ile bireylerin sol el tercihi arasında bir ilişkinin olmadığı fakat antioksidan savunma sisteminin bu hastalarda zayıfladığı sonucuna varıldı.

Anahtar Kelimeler:

Melatonin, Antioksidanlar, Astım, Glutatyon peroksidaz, Süperoksit dismutaz

Investigation of the relationships between laterality and antioxidants in bronchial asthmatic patients

The aim of this study was to investigate of the relationships between laterality and antioxidants in the patients with bronchial asthma. For this study permission was taken from etic comitee. In 60 facts, which are 30 patients who has bronchial asthma and 30 healthy individuals, the levels of superoxide dismutase, glutathione peroxidase in erytrocyte and serum melatonin have been determined. Morever, modifiye form of Geschwind Score, of handedness questionnaire has been applied for each fact. Right handedness is dominant in bronchial asthmatic patients, the levels of superoxide dismutase in erytrocyte, serum melatonin has been found meaningfully low according to control group. However, the levels of glutathione peroxidase in erytrocyte is low in bronchial asthmatic patients, no meaningful difference between two groups has been determined. A negative corelation has been observed between lateralite and the level of superoxide dismutase. In our study, the result, that there was no relationship between bronchial asthma and left handedness but antioxidant defence system was weakened asthmatic patients.

Keywords:

Melatonin, Antioxidants, Asthma, Glutathione Peroxidase, Superoxide Dismutase,

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