Betül YAZĞAN, Yener YAZĞAN

10715

Antioksidan redoks sistemi üzerinde metallotionin ve çinko ilişkisinin önemi

Metallotioninler (MT), stres yanıtına katılan, ağır metal bağlayıcı ve sisteinden zengin küçük proteinlerdir. İçerdikleri sülfür grupları sayesinde hücreleri oksidan ve elektrofilik moleküllerin etkilerinden korurlar. Esas rolleri tanımlanmamış MT proteinlerinin, işlevlerinin keşfi için yapılan çalışmalar devam etmektedir. İlk olarak, at böbreği korteksinden izole edip tanımlan bu proteinlerin, bütün canlı organizmalarda bulunduğu ve yaygın özelliklere sahip olduğu belirlenmiştir. Bu proteinlerin hayati rolleri, kadmiyum, civa gibi çevresel toksik metalleri bağlamaları ve çinko (Zn) ve bakır gibi fizyolojik önemi olan metallerin iyonize formlarını düzenlemeleridir. Zn'nin emilimi, hücre içi taşınması, mobilizasyonu, depolanması ve transferinde temel düzenleyici olarak rol alan MT'ler, serbest radikallerin yakalanmasında da önemli etkilere sahiptirler.

Importance of relationship metallothioneins and zinc on the antioxidant redox system

Metallothioneins (MT), participating in the stress response, and heavy metalbinding cysteine-rich small proteins. They protect cells the effects from oxidant and electrophilic molecules through sulfur group contents. For the discovery of functions of essential roles undefined MT proteins, studies are ongoing. They were firstly isolated and identified from horse kidney cortex proteins. Today they are present in all living organisms and have been determined to have common characteristics. The vital role of these proteins, such cadmium and mercury connect as the environmental toxic metals and zinc (Zn) and copper as well as the physiological significance of the metals are regulation of ionized forms. In the absorption of Zn, intracellular transport, mobilization, storage and transfer of Zn, which acts as a major regulator of MTs, have a major impact. The MTs have also important role in scavenge of free oxygen radicals.
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Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi-Cover
  • ISSN: 1300-7416
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1994
  • Yayıncı: SDÜ Basımevi / Isparta
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