Seyfullah KAN, Selvihan BEYSEL, Muhammed KIZILGÜL, Erman ÇAKAL, Adnan KARAİBRAHİMOĞLU, Merve İNANÇ, Uğur ACAR

Gestasyonel Diabetes Mellitus'un Kornea Biyomekanik Özellikleri Üzerine Etkisi

Amaç: Bu çalışmada gestasyonel diyabetes mellitus'un (GDM) korneal biyomekanik parametreler üzerindeki etkisini araştırmak amaçlanmıştır. Materyal-Metot: Çalışmaya GDM tanısı alan 38 hasta ile yaş ve gebelik haftaları uyumlu 34 sağlıklı gebe kadın katıldı. Herhangi bir oküler veya sistemik bozukluğu (glokom, tiroid bozuklukları, rosacea, bağ dokusu hastalıkları, vb.) ve oküler cerrahi veya travma öyküsü, kontakt lens veya herhangi bir topikal ilaç kullanan kişiler çalışma dışı bırakıldı. Katılımcıların sağ gözü incelendi. Oküler response analiz (ORA) cihazı ile elde edilen kornea histerezisi (CH), kornea direnç faktörü (CRF), Goldmann-korelasyonlu göz içi basıncı (IOPg) ve korneal kompanse edilmiş IOP (IOPcc) içeren kornea parametreleri istatistiksel olarak karşılaştırıldı. Bulgular: Katılımcıların ortalama yaş ve gebelik haftası GDM'li ve sağlıklı hamile kadınlarda sırasıyla 30,71±5,09 yıl, 25,95±1,56 hafta ve 29,97±4,10 yıl, 25,76±1,30 hafta idi. Yaş (p=0,502) veya gebelik haftası (p=0,594) arasında anlamlı fark bulunmadı. CH, CRF, IOPg ve IOPcc değerleri, GDM'li hamile kadınlarda, sağlıklı hamile kadınlardakine kıyasla daha yüksek bulunmuştur. Ancak parametrelerde istatistiksel olarak anlamlı bir fark yoktu (sırasıyla, p=0,183, p=0,303, p=0,732 ve p=0,330). Sonuç: Diyabetik hastalarda hiperglisemi, gözün diğer tüm katmanlarıyla birlikte korneada patolojik değişikliklere neden olur. Ancak kısa süreli hiperglisemi korneal biyomekanik parametreleri etkilemez.

Effect of Gestational Diabetes Mellitus on Corneal Biomechanical Characteristics

Objective: This study aimed to investigate whether gestationaldiabetes mellitus (GDM) affects the corneal biomechanicalparameters.Material-Method: Thirty-eight pregnant women, newlydiagnosed with GDM and, age- and gestational age-matched34 healthy pregnant females were enrolled in the study.Individuals having any ocular or systemic disorders (suchas glaucoma, thyroid disorders, rosacea, connective tissuediseases, etc.) and history of ocular surgery or trauma, contactlens or those using any topical medication were excluded fromthe study. The right eye of the participants was examined. Thecorneal parameters including corneal hysteresis (CH), cornealresistance factor (CRF), Goldmann-correlated intraocularpressure (IOPg), and the corneal compensated IOP (IOPcc),obtained by The Ocular Response Analyzer (ORA) devicewere compared statistically.Results: The mean and gestational age of the participants was30.71±5.09 years, 25.95±1.56 weeks and 29.97±4.10 years,25.76±1.30 weeks in pregnant females with GDM and healthypregnant females, respectively. No significant differences inage (p=0.502) or gestational age (p=0.594) were noted. Thevalues of CH, CRF, IOPg, and IOPcc were determined to behigher in pregnant females with GDM as compared to that inhealthy pregnant females. However, there was no statisticallysignificant difference in any other parameter (p=0.183,p=0.303, p=0.732 and p=0.330, respectively).Conclusions: Hyperglycemia in diabetic patients causespathological changes in the cornea, along with all the otherlayers of the eye. Short-term hyperglycemia does not affectthe corneal biomechanical parameters.

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