Nagehan YILMAZ, Büşra KORKMAZ, Şengül ERBEK, Ozgul BAYGİN, Fatih Mehmet KORKMAZ, Tamer TUZUNER

Türkiye'nin Kuzeydoğusunda reçete edilen pediatrik ilaçların karyojenik ve aşındırıcı potansiyelinin değerlendirilmesi: Bir in vitro çalışma

Amaç: Çalışmanın amacı, Türkiye Kuzeydoğu bölgesinde pediatrik kullanım için reçete edilen ilaçların karyojenik ve eroziv potansiyelini in vitro olarak değerlendirilmesidir. Gereç ve yöntem: Çalışmada pediatristler tarafından reçete edilen ilaçlar arasından 14 farklı ilaç grubuna ait 30 farklı ilaç seçildi. İlaçların pH, total titrasyon asitliği (TTA), toplam çözünebilir katı içeriği (TSSC), toplam şeker içeriği (TSC) ölçüldü. Elde edilen veriler SPSS istatistik yazılımı kullanılarak analiz edildi. Tüm gruplarda pH ve TTA, TSSC değerleri açısından karşılaştırma yapılırken Pearson ki-kare testi uygulandı. Bulgu:Test edilen ilaçların pH ortanca değerleri 3.11 ile 7.62 arasında değiştiği; ilaçların % 53.3’nün pH ortanca değerinin kritik pH (5.5) in altında olduğu tespit edildi. Ortanca değere göre TTA değerleri tüm gruplarda düşük olarak bulgulandı. En yüksek TTA değeri 23.8770 ve ikinci olarak 22.9540 olarak ölçüldü. En düşük TSSC değerinin 1.3320 ve en yüksek TSSC değerinin 1.4450 olduğu saptandı. Toplam şeker içerikleri analizinde kullanılan ilaçların %33 ‘ünde şeker içeriği tespit edildi. Sonuç: Analiz edilen ilaçlar, diş dokularında karyojenik ve eroziv potansiyel gösteren fizikokimyasal özellikler gösterdi. Bu doğrultuda sağlık profesyonelleri, ilaç üreticileri ve ebeveynler diş dokularına potansiyel olarak zararlı ilaçların tüketilmesinden kaynaklanan riskler hakkında bilinçlendirilmelidir.

Anahtar Kelimeler:

Erozyon, Mine, Oral likit ilaç

Evaluation of cariogenic and erosive potential of prescribed pediatric medicaments in Northeast of Turkey: An in vitro study

Aim: To purpose of the present study is to evaluate in vitro the cariogenic and erosive potential of the medicaments prescribed for pediatric use in the Northeastern Region of Turkey. Material and Methods: In the present study, 30 different medicaments of 14 different drug groups were selected among the medicaments prescribed by pediatricians. The pH, Total Titration Acidity (TTA), Total Soluble Solid Content (TSSC), Total Sugar Content (TSC) of the medicaments were measured. The data obtained in this way were analyzed by using the SPSS Statistics Software. The Pearson Chi-Square Test was used in all groups when comparing the pH, TTA and TSSC values. Results: It was determined that the median pH values of the medicaments that were tested ranged between 3.11 and 7.62; and 53.3 % of the medicaments had pH levels below the critical median value (5.5). It was found that the TTA values were low in all groups according to the median value. The highest TTA value was measured 23.8770 and the second was 22.9540.The lowest TSSC was found to be 1.3320, and the highest TSSC was 1.4450. Sugar content was detected in 33 % of the medicaments that were used in total sugar content analysis. Conclusions: The medicaments that were analyzed showed physical chemical properties showing cariogenic and erosive potentials in dental tissues. In this respect, healthcare professionals, drug manufacturers, and parents must be informed about the risks caused by the consumption of potentially harmful medicaments in dental tissues.

Keywords:

Erosion, Enamel, Oral liquid medicament,

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