Hidroksiklorokin Sülfat Kaynaklı Plazma Hücreli Gingivitis: Olgu Sunumu

Plazma hücreli gingivitis, dişeti bağ dokusunda yoğun plazma hücresi infiltrasyonu, klinik olarak sınırları belirgin eritematöz, ödematöz dişeti ile karakterize olan dişetinin etiyolojisi tam bilinmeyen nadir görülen benign bir durumudur. Dişeti kızarık, yumuşak bazen granüler görünür ve kolay kanar. Plazma hücreli gingivitisin allerjik menşeyli olduğu düşünülmektedir ve muhtemelen sakız, dişmacunu ya da çeşitli gıdalardaki bileşenlerle ilişkili olabilir. Maruz kalınan allerjenin kesilmesi ile lezyon iyileşmektedir. Bu olgu sunumunda, 62 yaşındaki bayan hasta dişetlerinde kanama ve kızarıklık nedeni ile kliniğimize başvurdu. Faz I periodontal tedaviden 1 hafta sonra dişetlerinde bariz eritem mevcuttu. Alınan biyopsi örneklerinin histopatolojik analizi sonucu plazma hücreli gingivitis teşhisi kondu. Allerjen olarak plazma hücreli gingivitise neden olan hidroksiklorokin isimli antiromatizmal ilacın kesilmesi sonucu dişetlerinde tam iyileşme gözlendi.

Anahtar Kelimeler:

Gingivitis, hidroksiklorokin, hipersensivite

Hydroxychloroquine Sulphate-Induced Plasma Cell Gingivitis: Case report

Plasma cell gingivitis is a rare benign condition of the gingiva of unknown exact etiology characterized by demarcated erythematous and edematous gingiva clinically and a heavy plasma cell infiltration into the gingival connective tissue. The gingiva appears red, friable, and sometimes granular and bleeds easily. Plasma cell gingivitis is thought to be allergic in origin, possibly related to components of chewing gum, dentifrices, or various diet components. Cessation of exposure to the allergen brings resolution of the lesion. In this case report, 62 years old female patient referred to our clinic because of gingival bleeding and erythema. Apparent erythema was still seen in gingiva 1 week after Phase I periodontal treatment. Plasma cell gingivitis was diagnosed after histopathologic analysis of biopsied tissues. Complete gingival healing was observed after cessation of anti-rheumatic drug named hydroxychloroquine as an allergen causing plasma cell gingivitis.

Keywords:

Gingivitis, hydroxychloroquine, hypersensitivity,

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