TSH DÜZEYİ NORMAL, DÜŞÜK VE YÜKSEK HASTALARDA VÜCUT KİTLE İNDEKSLERİNE GÖRE HDL DÜZEYLERİNİN KARŞILAŞTIRILMASI

Amaç Obezite dünyada prevelansı gittikçe artan bir sağlık problemidir. Obezite ayrıca dislipideminin önemli nedenlerinden biridir Son yıllarda tiroid hormon düzeyleri ve vücut kitle indekslerini (VKİ) karşılaştıran pek çok çalışma vardır. Ayrıca tiroid hormon testleri ve lipid profilini inceleyen çalışmalarda mevcuttur. Bu çalışmanın amacı, erişkin bireylerde Tiroid Stimulan Hormon (TSH) düzeyleri normal, düşük ya da yüksek olmasının vücut kitle indeksine göre Yüksek Dansiteli Lipoprotein (HDL) düzeylerine etkisinin değerlendirilmesidir. Gereç ve Yöntem Çalışma retrospektif olarak veri analiz yöntemiyle dizayn edildi. Aralık 2016- Eylül 2020 tarihleri arasında özel bir üniversite hastanesinin Checkup polikliniğine başvurmuş; Herhangi bir tiroid ilacı kullanmayan, TSH, VKİ, HDL değerleri bakılmış, 18 yaş üstü bireylerin verileri toplandı(n=1621). Sosyo-demografik veri olarak ayrıca her hasta için yaş ve cinsiyet verileri de kaydedildi. Veriler SPSS 25.0 paket programıyla analiz edildi. Sürekli değişkenler ortalama ± standart sapma ve ortanca (min, maks), kategorik değişkenler ise sayı ve yüzde olarak ifade edildi. Verilerin normal dağılıma uygunluğu Kolmogorov Smirnov testi ve histogramlar ile incelendi. Bağımsız grup incelemelerinde; Mann Whitney U testi ve Kruskal Wallis Varyans Analizi (post hoc: Bonferroni düzeltmeli Mann Whitney U testi) kullanıldı. Kategorik değişkenler arasındaki farklılıkların incelenmesinde ise Ki kare testi kullanıldı. Tüm analizlerde p<0,05 istatistiksel olarak anlamlı kabul edildi. Bulgular Normal kilolu olan kişilerde TSH sınıflarına göre HDL değerleri istatistiksel olarak anlamlı farklılık gösterdi. TSH değeri 0.5 ve 4 mİU/mL arasında olan kişilerin HDL değerleri TSH değeri 4 mİU/mL ve üzerinde olan kişilere göre anlamlı şekilde düşük bulundu (p=0,005). Obez kişilerde ise TSH durumlarına göre HDL durumlarına bakıldığında istatistiksel olarak anlamlı farklılık olmadığı görüldü (p>0,05). Sonuç Çalışmamızda normal kilolu olan kişiler arasında TSH değeri normal olanların HDL değerleri, TSH değeri yüksek olanlara göre anlamlı şekilde düşük bulundu. Bu konuda hem erişkin hem çocuklarda yapılan bazı çalışmalar olsa da hala araştırmaya açık bir konudur. Bu alanda yapılacak yeni çalışmalar ile konu hakkında daha ayrıntılı ilişkiler saptanabilecektir.

Anahtar Kelimeler:

Obezite, HDL Kolesterol, Tiroid Stimulan Hormon, Vücut Kitle İndeksi, Obezite, HDL Kolesterol

COMPARISON OF HDL LEVELS ACCORDING TO BODY MASS INDEXES IN PATIENTS WITH NORMAL, LOW AND HIGH TSH LEVELS

Objective The prevalence of obesity is an increasing health problem throughout the world. Obesity is also one of the major causes of dyslipidemia. There have been many studies comparing thyroid hormone levels and body mass indexes (BMI) in recent years. There are also studies available in thyroid hormone tests and studies examining lipid profile. The aim of this study is to evaluate the effect of normal, low or high Thyroid Stimulated Hormone (TSH) levels on High Density Lipoprotein (HDL) levels according to body mass index in adult individuals. Material and Methods The study was retrospectively designed with data analysis method. The study was applied in the private university hospital Checkup clinic between December 2016 and September 2020; TSH, VKİ, HDL values were studied, and data of individuals over 18 years of age were collected (n=1621). As sociodemographic data, age and gender data were also recorded for each patient. Data was analyzed via SPSS 25.0 package program. Continuous variables are expressed as mean ± standard deviation and median (min, max), and categorical variables are expressed as numbers and percentages. Kolmogorov Smirnov Smirnov test and histograms was used to examine compliance of data to normal distribution. In independent group reviews Mann Whitney U test and Kruskal Wallis Variance Analysis (post hoc: Mann Whitney U test with Bonferroni correction) were used. In the examination of the differences between categorical variables, the Ki square test was used. All analysis P<0.05 was accepted as statistically significant. Results HDL values differed statistically significantly in people who were normal weight compared to TSH classes. HDL values of people with TSH values between 0.5 and 4 mlU/mL were found to be significantly lower than those with a TSH value of 4 mlU/mL or higher (p=0.005). In obese people, it was observed that there was no statistically significant difference considering their HDL status according to TSH status (p>0.05). Conclusion In our study, HDL values of normal people with normal TSH value were found to be significantly lower than those with high TSH values among people who were normal weight. Although there are some studies in both adults and children, it is still open to research. It would be possible to detect more detailed relationships on the subject with new studies to be carried out in this field.

Keywords:

Obesity, HDL Cholesterol, Thyroid Stimulating Hormone, Body Mass İndex, Obesity, HDL Cholesterol,

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