Lipid peroksidasyonu ve antioksidan enzimler

Reaktif oksijen türlerinin (ROS) sağlık üzerindeki patolojik ve fizyolojik etkileri son yıllarda vurgulanmaktadır. Mitokondri tarafından ROS üretiminde oksidatif stresin ana neden olduğu genellikle düşünülmektedir. ROS katalaz, superoksid dismutaz, glutatyon peroksidaz, vitamin C, Vitamin E, vitamin A, pruvat, glutatyon, taurin, hiptaurin gibi antioksidan savunma mekanizmaları tarafından nötralize edilmektedir. Hastalıklarla ilişkili olan oksidatif hasar biyobelirteçleri hastalıkların teşhis ve idaresinde kullanılmaktadır.

Anahtar Kelimeler:

lipid peroksidasyonu, oksidatif stres, antioksidanlar

Lipid peroxidation and antioxidant enzymes

The role of reactive oxygen species (ROS) in the pathologic and physiologic effects on health has been emphasized in recent years. Production of ROS by mitochondria is generally thought to be the main cause of oxidative stres (OS). ROS are neutralized by various antioxidant defense mechanisms such as catalase, superoxide dismutase and glutathione peroxidase, vitamin C, vitamin E, vitamin A, pyruvate, glutathione, taurine and hypotaurine. Biomarkers of oxidative damage associated with human diseases could be used to diagnose and manage the diseases.

Keywords:

lipid peroxidation, oxidative stres, antioxidants,

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