Ali Gokhan OZYİLDİZ, Mustafa ÇETİN, Savaş ÖZER, Oguzhan Ekrem TURAN, Hüseyin DURAK, Turan ERDOĞAN

Erken Saç Beyazlaması Sağlıklı Genç ve Orta Yaşlı Erkekler için Hipertansiyonun Belirleyicisi midir?

Amaç: Oksidatif stres, hipertansiyon (HT) gelişiminde temel faktörlerden biridir. Saç beyazlaması oksidatif stresin görsel bir işaretidir. Erken saç beyazlaması yoğunluğunun HT gelişimini öngörebileceğini varsaydık ve bunu test etmeyi amaçladık.Gereç ve Yöntemler: Saç beyazlığı farklı derecelerde 172 sağlıklı erkek çalışmaya dahil edildi ve ortalama 86 ay sonunda değerlendirildi. Takip süresi boyunca HT tanısı alan hastaların verilerini sağlıklı kalanlarla karşılaştırdık.Bulgular: Takip süresince 172 hastanın 53'üne (% 32) HT tanısı konuldu. Demografik özellikler açısından yaş (41,48 ± 6,39 vs 44,36 ± 5,25 yıl; p=0,013), bel çevresi (97,52 ± 10,87 vs 104,80 ± 11,94 cm; p=0,004) ve vücut-kitle indeksi (27,61 ± 3,56 vs 30,20 ± 3,55 kg / m2; p<0,001) HT grubunda daha fazla iken, sigara içme öyküsü (p=0,211) gruplar arasında benzerdi. Tek değişkenli analiz sonucunda karotis intima-media kalınlığı (KIMK)(p=0,013), gama-glutamil transferaz (GGT)(p=0,021) ve ürik asit (p<0,001) seviyeleri HT grubunda daha yüksek; tahmini glomerüler filtrasyon hızı (tGFH)(p=0,039) ve yüksek dansiteli lipoprotein (YDL)(p=0,026) düzeyleri ise daha düşüktü. Saç beyazlığı derecesi ve yoğunluğu açısından gruplar arasında fark yoktu. Çoklu değişkenli analiz yapıldığında, yaş (OR=0,143, 95%CI (1,002-1,328), p=0,046), tGFH (OR=-0,058, 95%CI (0,895-0,995), p=0,032), ürik asit (OR=0,567, 95%CI (1,032-3,015), p=0,038), GGT (OR=0,030, 95%CI (1,001-1,060), p=0,041) ve YDL kolesterol (OR=-0,129, 95%CI (0,783- 0,986), p=0,028) de nova HT ile bağımsız ilişkiliydi. Vücut-kitle indeksi, KIMK ve lökosit miktarı iki grup için benzerdi. Sonuç: Erken saç beyazlaması, genç ve orta yaşlı sağlıklı erkeklerde HT gelişimini belirlemede öngörücü değildir.

Anahtar Kelimeler:

Hipertansiyon, oksidatif stres, genç, orta yaş, erkek, saç

Is Premature Hair Whitening a Predictor of Hypertension for Healthy Young and Middle-Aged Men?

Objective: Oxidative stress is one of the essential factors in the development of Hypertension (HT). Hair whitening is a visual sign of oxidative stress. We hypothesized that the intensity of premature hair whitening might predict HT development, and we aimed to test it. Materials and Methods: A total of 172 healthy males with different stages of hair whitening were included in the study and evaluated after an average of 86 months. During the follow-up, we compared the data of patients diagnosed with HT to those who remained healthy. Results: Fifty-five (32%) of 172 patients were diagnosed with HT during follow-up period. In terms of demographic characteristics, age (41.48 ± 6.39 vs 44.36 ± 5.25 years; p=0.013), waist circumference (97.52 ± 10.87 vs 104.80 ± 11.94 cm; p=0.004), and body-mass index (27.61 ± 3.56 vs 30.20 ± 3.55 kg/m2; p<0,001) were higher in the HT group, whereas smoking history (p=0.211) was similar between the groups. In univariate analysis carotid intima-media thickness (CIMT)(p=0.013), gamma-glutamyl transferase (GGT)(p=0.021), and uric acid (p<0.001) levels were higher in the HT group; on the contrary, estimated glomerular filtration rate (eGFR)(p=0.039) and high-density lipoprotein (HDL) levels (p=0.026) were lower in this group. There was no difference between groups in terms of hair whitening stage and intensity. In multivariate analysis age (OR=0.143, 95%CI (1.002-1.328), p=0.046), eGFR (OR= -0.058, 95%CI (0.895-0.995), p=0.032), uric acid (OR=0.567, 95%CI (1.032-3.015), p=0.038), GGT (OR=0.030, 95%CI (1.001-1.060), p=0.041), and HDL (OR=-0.129, 95%CI (0.783- 0.986), p=0.028) were independently associated with de nova HT. Body-mass index, CIMT, and the leukocyte count were similar between the groups. Conclusion: Premature hair whitening is not predictive in determining the development of HT in young and middle-aged healthy men.

Keywords:

Hypertension, young, middle-aged, male, hair, oxidative stress,

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