Muhammed Cihad ÇELİK, Serdal BAŞTUĞ, Abdullah Nabi ASLAN, Hacı Ahmet KASAPKARA, Mehmet Murat YİĞİTBAŞI, Yunus Emre ÖZBEBEK, Engin BOZKURT

Biküspit Aort Kapak Hastalarında Kırmızı Hücre Dağılım Aralığı Ile Asendan Aort Çapı Arasındaki Ilişki

Amaç Kırmızı kan hücresi dağılım genişliği (KHDG) ve nötrofi l lenfosit oranı (NLO) bazı kardiyak durumların ciddiyetinin ve progresyonunun değerlendirilmesinde önemli bir rol oynar. Biküspit aortik kapak (BAK)- ilişkili aortopati sık görülür ve progresyonunu bireysel hastalarda tahmin etmek zordur. Bu çalışmada, biz BAK hastalarında KHDG’nin serum düzeyleri ve NLO ile asendan aort çapı (AAÇ) arasındaki ilişkiyi araştırmayı amaçladık. ( Sakarya Tıp Dergisi, 2018, 8(2):327-335 ). Gereç ve Yöntem Toplamda 182 ardışık BAK hastası bu tanımlayıcı ve metodolojik çalışmaya alındı. KHDG düzeyi ve NLR için tam kan sayımı incelendi. Hastalar AAÇ’lerine göre 2 gruba ayrıldı ve AAÇ 3.9 ve üzeri olan hastalar grup 1, 3.9’ un altında olan hastalar ise grup 2’ye dahil edildi. Bulgular NLO grup 1 hastalarında grup 2’dekilere kıyasla anlamlı olarak daha yüksekti. KHDG seviyeleri benzerdi. Tekli korelasyon analizinde, AAÇ ile KHDG ve NLO arasında anlamlı pozitif korelasyon saptandı. Çoklu regresyon analizinde RDW’nin (odds ratio (OR): 1.78, 95% confi dence interval (CI): 1.36 – 2.44, P = 0.01) asendan aort dilatasyonunun bağımsız bir belirteci olduğu belirlendi. Receiver operating characteristic (ROC) analizinde KHDG için > 13.0% sınır değerinin asendan aort dilatasyonu tanısı için %58 duyarlılık ve %79 özgüllüğe sahip olduğu bulundu. Sonuç KHDG ve NLO asendan aort dilatasyonu olan BAK hastalarında AAÇ ile pozitif koreledir. Bu belirteçler bu hastalarda asendan aort dilatasyonunun hem patogenezi hem de progresyonunda infl amasyonun rolü olduğunu gösterebilir.

Relation of Red Cell Distribution Widht with Ascending Aortic Diameter in Bicuspid Aortic Valve Patients

Objective Red cell distribution widht (RDW) and neutrophil to lymphocyte ratio (NLR) plays a signifi cant role in assessing the severity and progressionof some cardiac conditions. Bicuspid aortic valve (BAV)-associated aortopathy is common and its progression for individual patients isdiffi cult to predict. In this study, we aimed to investigate the association between serum levels of RDW, NLR and ascending aortic diameter(AAd) in BAV patients. Sakarya Med J, 2018, 8(2):327-335 )Materials andMethodsThis is a descriptive and methodologic study which included a total of 182 consecutive patients with a BAV. Complete blood counts wereanalyzed for RDW level and NLR. Patients were divided into two groups based on their AAd and patients with AAd of 3.9 and above wereincluded in group 1, while those below 3.9 in group 2.Results NLR was signifi cantly higher in group 1 patients than those in group 2. RDW levels were similar. In univariate correlation analysis, a positivecorrelation was found between AAd and RDW and NLR in group 1 patients. In multivariate logistic regression analysis, RDW (odds ratio(OR): 1.78, 95% confi dence interval (CI): 1.36–2.44, P = 0.01) remained as independent correlates of AAd in the patient population.Receiver operating characteristic (ROC) curve analysis revealed that a RDW measurement >13.0% predicted ascending aort dilatation(AAD) with a sensitivity of 58% and a specifi city of 79%.Conclusion RDW and NLR are positively correlated with AAd in BAV patients with AAD. These markers may point out the role of infl ammation both inthe pathogenesis and progression of AAD in these patients.

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