Kolorektal Kanser ve D Vitamini

Kolorektal kanser dünyada üçüncü sırada yaygın görülen kanser türüdür. Kolorektal kanser risk faktörlerinden biri düşük D vitamini düzeyidir. D vitamini eksikliği dünyada artış gösteren bir sağlık sorunudur. D vitamini aktif formu kalsitriol olarak bilinen 1,25-Dihidroksikolekalsiferoldur. Bu form bazı biyolojik süreçler ve immün sistem düzenlenmesinde görev alır. D vitamini kolon, meme, prostat gibi pek çok kanser türü ile ilişkilidir. Tedavi sürecinde de önemli etkileri olan D vitaminin cerrahi müdahale veya kemoterapi tedavisi sonrası plazma seviyesinin yüksek olması daha iyi sağ kalım ile ilişkili bulunmuştur.

Anahtar Kelimeler:

Beslenme, D vitamini, D vitamini reseptörü, Kanser, Kolorektal kanser

Colorectal Cancer and Vitamin D

Colorectal cancer is the third most common type of cancer in world. One of the risk factors for colorectal cancer is low vitamin D level. Vitamin D deficiency is an increasing health problem in the world. The active form of vitamin D is 1,25-dihydroxy vitamin D, known as calcitriol. This form is involved in some biological processes and immune system regulation. Vitamin D is associated with many types of cancer such as colon, breast, prostate. The high levels of vitamin D, which has important effects in the treatment process, has been found to be associated with better survival after surgery or chemotherapy treatment.

Keywords:

Nutrition, Vitamin D, Vitamin D receptor, Cancer, Colorectal cancer,

PDF

___

1. Padmanabhan S, Waly MI, Taranikanti V, Guizani N, Rahman MS, Ali A, Al-Attabi Z, Deth RC. Modifiable and non-modifiable risk factors for colon and rectal cancer. Bioactive Components, Diet and Medical Treatment in Cancer Prevention. 2018; 121-130.
2. GLOBOCAN. İnternational Agency for Research on Cancer, World Health Organization. Erişim Adresi: http://gco.iarc.fr/today/online-analysis-pie. [Erişim tarihi 06.10.2020]
3. Camara AB, Brandao IA. The role of vitamin D and sunlight incidence in cancer. Anti-Cancer Agent in Medical Chemistry. 2019; 19(11): 1418-1436.
4. Alptekin İM. Anti-Kanser Etkiler Işığında D vitamini ve Kanser. ACU Sağlık Bil Derg. 2017;2:70-74.
5. O’Neill AM, Burrington CM, Gillaspie EA, Lynch DT, Horsman MJ, Greene MW. High-fat westren diet-induced obesity contributes to increased tumor growth in mouse models of human colon cancer. Nutrition Research. 2016; 36: 1325-1334.
6. Akın H, Tözün N. Diet, Mikrobiota and Colorectal Cancer. J Clin Gastroenterol. 2014; 48(1): 67-69.
7. Zamora-Ros R, Cayssials V, Jenab M, Rothwell J, Fedirko V, Aleksandrova K, et. al. Dietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. European Journal of Epidemiology. 2018; 33(11): 1063-1075.
8. T.C. Sağlık Bakanlığı Halk Sağlığı Genel Müdürlüğü Kanser Dairesi Başkanlığı. 2014 Yılı Türkiye Kanser İstatistikleri. https://hsgm.saglik.gov.tr/tr/kanser-istatistikleri/yillar/2014-yili-turkiye-kanser-istatistikleri.html. [Erişim tarihi 06.10.2020]
9. Ratjen I, Schafmayer C, Di Giuseppe R, Waniek S, Plachta-Danielzik S, Koch M et. al. Postdiagnostic Mediterranean and Healthy Nordic Dietary Patterns Are Inversely Associated with All-Cause Mortality in Long-Term Colorectal Cancer Survivors. The Journal of Nutrition. 2017; 147(4): 636-644.
10. Bastide NM, Chenni F, Audebert M, Santarelli R, Tache S, Naud N et. al. A Central Role for Heme Iron in Colon Carcinogenesis Associated with Red Meat Intake. Cancer Research. 2015; 75(5): 870-879.
11. Song Y, Liu M, Yang F, Cui L, Lu X, Chen C. Dietary Fibre and the Risk of Colorectal Cancer: a Case-Control Study. Asian Pacific Journal of Cancer Prevention. 2015; 16(9): 3747-3752.
12. Qamar TR, Igbal S, Syed F, Nasir M, Rehman H, Iqbal MA et. al. İmpact of novel prebiotic galacto-oligosaccharides on various biomarkers of colorectal cancer in wister rats. Int J Mol Sci. 2017; 18: 1785-1797.
13. Rivera-Huerta, M, Lizárraga-Grimes V, Castro-Torres I, Tinoco-Méndez M, Macías-Rosales L, Sánchez-Bartéz F et. al. Functional Effects of Prebiotic Fructans in Colon Cancer and Calcium Metabolism in Animal Models. BioMed Research International. 2017: 1-10.
14. McNabney SM, Henagan TM. Short Chain Fatty Acids in the Colon and Peripheral Tissues:A focus on Butyrate, Colon Cancer, Obesity and İnsulin Resistance. Nutrients. 2017; 9(12):1348. doi:10.3390/nu9121348.
15. Uzunlulu M, Telci Caklili Ö, Oğuz A. Association between metabolic syndrome and cancer. Ann Nutr Metab. 2016; 68: 173-179.
16. O’Keefe SJD. Diet, microorganisms and their metabolites, and colon cancer. Nat Rev Gastroenterol Hepatol. 2016; 13(12): 391-706.
17. Ward HA, Norat T, Overvad K, Dahm CC, Bueno-de-Mesquita HB. Pre-diagnostic meat and fibre intakes in relation to colorectal cancer survival in the European Prospective Investigation into Cancer and Nutrition. British Journal of Nutrition. 2016; 116(2): 316-325.
18. Wang W, Yu S, Huang S, Deng R, Ding Y, Wu Y. A complex role for calcium signaling in colorectal cancer development and progression. Mol Cancer Res. 2019; 17(11): 2145-2153.
19. Bizzaro G, Antico A, Fortunato A, Bizzaro N. Vitamin D and Autoimmune Diseases: İs Vitamin D Receptor(VDR) Polymorphism the Culprit? IMAJ. 2017; 19(7): 438-443.
20. Meeker S, Seamons A, Maggio-Price L, Paik J. Protective links between vitamin D, inflammatory bowel disease and colon cancer. World J Gastroenterol. 2016; 22(3): 933-948.
21. T.C. Sağlık Bakanlığı. Türkiye Beslenme Rehberi – TÜBER 2015. T.C. Sağlık Bakanlığı Yayın No: 1031, Ankara 2016. S. 172, 217.
22. Vurgun E, Evliyaoğlu O, Yıldırmak S. Kanıta dayalı laboratuvar: D vitamini yetersizlik sınırlarının belirlenmesi. Med Bull Haseki. 2016; 54: 76-82.
23. Al-Ghafari AB, Balamash KS, Doghaither AA. Relationship between serum vitamin D and calcium levels and vitamin D gene polymorphisms in colorectal cancer. BieMed Research İnternational. 2019. Doi: https://doi.org/10.1155/2019/8571541.
24. Feldman D, Krishnan AV, Swami S, Giovannucci E, Feldman BJ. The role of vitamin D in reducing cancer risk and progression. Nature. 2014; 14: 342-357.
25. Lu R, Zhang YG, Xia Y, Sun j. Imbalance of autophagy and apoptosis in intestinal epithelium laching the vitamin D receptor. FASEB J. 2019. doi: 10.1096/fj.201900727R
26. Paubelle E, Zylbersztein F, Maciel TT, Carvalho C, Mupo A, Cheok et al. Vitamin D Receptor Controls Cell Stemness in Acute Myeloid Leukemia in Normal Bone Marrow. Cell Rep. 2020; 30(3): 739-754.e4.
27. Zhou X, Chen C, Zhong Y, Zhao F, Hao Z, Xu Y et al. Effect and mechanism of vitamin D on the development of colorectal cancer based on intestinal flora disorder. J Gastroenterol Hepatol. 2019; 35(6): 1023-1031.
28. Yang H, Wang Z, Jin M, Zhang HM, Chen XF, et al. Effects of Vitamin D Receptor on Mucosal Barrier Proteins in Colon Cells under Hypoxic Environment. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2019; 41(4): 506-511.
29. Ranji P, Agah S, Heydari Z, Rahmati-Yamchi M, Alizadeh AM. Effects of Lactobacillus acidophilus and Bifidobacterium bifidum probiotics on the serum biochemical parameters and the vitamin D and leptin receptor genes on mice colon cancer. Iranian Journal of Basic Medical Sciences. 2019; 22(6): 631-636.
30. Yi C, Huang C, Huan W, Wang C, Dong L, Xu G et al. Association study between CYP24A1 gene polymorphisms and cancer risk. Payhology-Research and Practice. 2020. https://doi.org/10.1016/j.prp.2019.152735
31. Wu X, Hu W, Lu L, Zhao Y, Zhaou Y, Xiao Z et al. Repurposing vitamin D for treatment of human malignancies via targeting tumor microenvironment. Acta Pharmaceutica Sinica B. 2019; 9(2): 203-219.
32. Markotic A, Langer S, Kelava T, Vucic K, Turcic P, Tokic T et al. Higher Post-Operative Serum Vitamin D Level is Associated with Better Survival Outcome in Colorectal Cancer Patients. Nutr Cancer. 2019; 71(7): 1078-1085.
33. Fuchs MA, Yuan C, Sato K, Niedzwiecki D, Ye X, Saltz LB et al. Predicted Vitamin D Status and Colon Cancer Recurrence and mortality in CALGB 89803(Alliance). Annals of Oncology. 2017; 28(6): 1359–1367.