KÖPEK ATOPİK DERMATİTİSİNDE TEŞHİS VE ALERJEN TAYİNİNDEKİ GÜNCEL YAKLAŞIMLAR
Köpek atopik dermatitis (KAD), genetik yatkınlığı olan inflamatuar ve kaşıntılı bir deri hastalığıdır. Hastalığın klinik bulgularındaki farklılaşma, genetik faktörlere bağlı klinik bulgular, lezyonların derecesi ve sekonder enfeksiyonların varlığı diğer deri hastalıklarına benzerlik gösterebileceği için atopik dermatitis (AD) tanısını karmaşık hale getirebilir. Köpek AD tanısını koyabilmek için benzer klinik kriterleri ve bulguları taşıyan olası tüm nedenler ekarte edilmelidir. Tüm bunlardan sonra KAD tanısı konulan hastalarda alerji testleri ile potansiyel alerjenlerin kimliğinin belirlenerek buna özgü alerjen spresifik immunoterapi uygulamasına başlanılmalıdır.
New Trends in the Diagnosis and Allergen Determination of Canine Atopic Dermatitis
Canine atopic dermatitis (AD) is a common, genetically predisposed, inflammatory and pruritic skin disease. The variation in clinical presentations, due to genetic factors, the extent of the lesions, the stage of the disease, secondary infections, as well as resemblance to other non-atopic related skin diseases, can complicate the diagnosis of canine AD. In conclusion, the diagnosis of canine AD is based on meeting clinical criteria and ruling out other possible causes with similar clinical signs. Once the clinical diagnosis of canine AD is made, allergy testing can be performed to identify potential causative allergens for allergen-specific immunotherapy
___
- 1. Halliwell R. Revised nomenclature for veterinary
allergy. Vet Immunol Immunopathol 2006; 114:207
-208.
- 2. DeBoer DJ, Hillier A. The ACVD task force on canine
atopic dermatitis (XV): fundamental concepts in
clinical diagnosis. Vet Immunol Immunopathol
2001; 81:271-276.
- 3. Nuttall T. The genomics revolution: will canine
atopic dermatitis be predictable and preventable?
Vet Dermatol 2013; 24:13-14.
- 4. Aytuğ N, Kanat Ö, Kömürcü B. Köpeklerin atopik
dermatitisi. Turkiye Klinikleri J Vet Sci Intern MedSpecial Topics 2017; 3:202-208.
- 5. Olivry T, DeBoer DJ, Favrot C, et al. Treatment of
canine atopic dermatitis: 2015 updated guidelines
from the International Committee on Allergic
Diseases of Animals (ICADA). BMC Veterinary
Research 2015; 11: 210.
- 6. Favrot C, Steffan J, Seewald W, et al. A prospective
study on the clinical features of chronic canine
atopic dermatitis and its diagnosis. Vet Dermatol
2010; 21:23-31.
- 7. Willemse TA. Atopic dermatitis: a review and reconsideration of diagnostic criteria. JSAP 1986; 27: 771
-778.
- 8. Pre´laud P, Guague`re E, Alhaidari Z, et al. Reevaluation of diagnostic criteria of canine atopic
dermatitis. Rev Med Vet 1998; 149:1057-1064.
- 9. Hensel P, Santoro D, Favrot C, et al. Canine atopic
dermatitis: detailed guidelines for diagnosis and
allergen identification. BMC Veterinary Research
2015; 11: 1-13.
- 10. Bruet V, Bourdeau PJ, Roussel A, Imparato L, Desfontis JC. Characterization of pruritus in canine
atopic dermatitis, flea bite hypersensitivity and flea
infestation and its role in diagnosis. Vet Dermatol
2012; 23:487-493.
- 11. Miller WH, Griffin CE. Campbell KL. In: Small Animal
Dermatology. 7th ed. St.Louis: WB Elsevier. 2013; p
363-431.
- 12. Olivry T, Deboer DJ, Prelaud P, Bensignor E. International Task Force on Canine Atopic Dermatitis. Food
for thought: pondering the relationship between
canine atopic dermatitis and cutaneous adverse
food reactions. Vet Dermatol 2007; 18:390-391.
- 13. Picco F, Zini E, Nett C, Naegeli C, Bigler B, Rufenacht
S, et al. A prospective study on canine atopic dermatitis and food-induced allergic dermatitis in Switzerland. Vet Dermatol 2008; 19:150-155.
- 14. Zur G, Ihrke PJ, White SD, et al. Canine atopic dermatitis: a retrospective study of 266 cases examined at the University of California, Davis, 1992-
1998. Part I. Clinical features and allergy testing
results. Vet Dermatol 2002; 13:89-102.
- 15. Griffin CE, DeBoer DJ. The ACVD task force on canine atopic dermatitis (XIV):clinical manifestations
of canine atopic dermatitis. Vet Immunol Immunopathol 2001; 81:255-269.
- 16. Olivry T, Saridomichelakis M. International Committee on Atopic Diseases of A. Evidence-based guidelines for anti-allergic drug withdrawal times before
allergen-specific intradermal and IgE serological
tests in dogs. Vet Dermatol 2013; 24:225-249.
- 17. Hensel P, Austel M, Wooley RE, et al. In vitro and in
vivo evaluation of a potentiated miconazole aural
solution in chronic Malassezia otitis externa in dogs.
Vet Dermatol 2009; 20:429-434.
- 18. Marsella R, Sousa CA, Gonzales AJ, et al. Current
understanding of the pathophysiologic mechanisms
of canine atopic dermatitis. J Am Vet Med Assoc
2012; 241:194-207.
- 19. Hillier A, DeBoer DJ. The ACVD task force on canine
atopic dermatitis (XVII): intradermal testing. Vet
Immunol Immunopathol 2001; 81:289-304.
- 20. Hensel P, Austel M, Medleau L, et al. Determination
of threshold concentrations of allergens and evaluation of two different histamine concentrations in
canine intradermal testing. Vet Dermatol 2004;
15:304-308.
- 21. Bauer CL, Hensel P, Austel M, et al. Determination of
irritant threshold concentrations to weeds, trees
and grasses through serial dilutions in intradermal
testing on healthy clinically non allergic dogs. Vet
Dermatol 2010; 21:192-197.
- 22. Suto A, Suto Y, Onohaga N, et al. Food allergens inducing a lymphocyte-mediated immunological reaction in canine atopi-like dermatitis. J Vet Med Sci
2015; 77:251-254.
- 23. Ownby DR. Clinical significance of immunoglobulin
E. In : Middleton EJ, Reed CE, Ellis EF (eds), Allergy:
Principles and Practice. 5th ed. Mosby, St. Louis,
1998; pp 770-782.
- 24. Foster AP, Littlewood JD, Webb P, et al. Comparison
of intradermal and serum testing for allergenspecific IgE using a Fc epsilon RI alpha-based assay
in atopic dogs in the UK. Vet Immunol Immunopathol 2003; 93:51-60.
- 25. Park S, Ohya F, Yamashita K, et al. Comparison of
response to immunotherapy by intradermal skin
test and antigen-specific IgE in canine atopy. J Vet
Med Sci 2000; 62:983-988.
- 26. Hillier A, Griffin CE. The ACVD task force on canine
atopic dermatitis (X): is there a relationship between canine atopic dermatitis and cutaneous adverse food reactions? Vet Immunol Immunopathol
2001; 81:227-231.
- 27. Cunha VE, Faccini JL. Use of histamine phosphate
for the interpretation of intradermal skin tests in
dogs. Vet Rec 2009; 165:723-724.
- 28. Temizel EM, Aytug N. Intradermal Testing Results
and Clinical Features in Dogs with Atopic Dermatitis
in Turkey. J Biol Environ Sci 2011; 5:87-89.
- 29. Temizel EM, Cihan H, Akhtardanesh B, et al. Effect of
prednisolone and cetirizine on D. farinae and histamine-induced wheal and flare response in healthy
dogs. Tierärztliche Praxis K: Kleintiere/Heimtiere
2011; 39:25-30.
- 30. Saevik BK, Ulstein TL, Larsen HJ. Evaluation of a
commercially available enzyme-linked immunosorbent assay for the detection of allergen-specific IgE
antibodies in dogs. Res Vet Sci 2003; 74:37-45.
- 31. Plant JD, Neradelik MB, Polissar NL, et al. Agreement between allergen-specific IgE assays and ensuing immunotherapy recommendations from four
commercial laboratories in the USA. Vet Dermatol
2014; 25:15-16.
- 32. Marsella R, Kunkle GA, Vaughn DM, et al. Doubleblind pilot study on the effects of ketoconazole on
intradermal skin test and leukotriene C4 concentration in the skin of atopic dogs. Vet Dermatol 1997;
8:3-10.
- 33. Goldman C, Rosser Jr E, Petersen A, et al. Investigation on the effects of cyclosporine (Atopica) on intradermal test reactivity and allergen specific immunoglobulin (IgE) serology in atopic dogs. Vet
Dermatol 2010; 21:393-399.
- 34. Martin DD, Martin AL. Pain management and anesthesia in veterinary dermatology. Vet Clin North Am
Small Anim Pract 2006; 36:1-14.
- 35. Kennis RA, Robertson SA, Rosser Jr EJ, et al. Effects
of propofol anesthesia on intradermally injected
histamine phosphate in clinically normal dogs. Am J
Vet Res 1998; 59:7-9.
- 36. Graham LF, Torres SM, Jessen CR, et al. Effects of
propofol-induced sedation on intradermal test reactions in dogs with atopic dermatitis. Vet Dermatol
2003; 14:167-176.