Bilge Nur ÇÖL, Edanur ÇELİK, Müveddet Emel ALPHAN

COVID-19 HASTALARINDA OBEZİTENİN MORTALİTE ÜZERİNE ETKİSİ

COVID-19 pandemisi, küresel sağlık açısından büyük bir krize neden olmuştur. Küresel düzeyde tanımlanan toplam vaka sayısı 200 milyonu aşmıştır. Dört milyondan fazlası ölümle sonuçlanmıştır. SARS-CoV-2 virüsünün neden olduğu bu ağır solunum yolu enfeksiyonunda, lenfopeni ve bozulmuş bağışıklık tepkisi görülmektedir. Obezitenin viral enfeksiyonlarda iyileşme süresinde uzama ve daha kötü klinik sonuçlarla ilişkisi uzun zamandır bilinmektedir. Son yıllarda yağ dokusunun endokrin işlevi konusunda artan veriler obezitenin sadece bir risk faktörü değil aynı zamanda bir hastalık olarak düşünülmesi gerektiğini göstermektedir. Bu konuda yapılan çalışmalar obez hastaların ve komorbiditelerinin, hastaneye yatış ve mekanik ventilasyon gerektiren ciddi tablolar geliştirmeye daha yatkın olabildiğini göstermektedir. Çalışmalar aynı zamanda obezite varlığında COVID-19 enfeksiyonu ile ilişkili morbidite ve mortaliteyi azaltmak için özel dikkat gösterilmesi gerektiğine işaret etmektedir. Bu derlemede, yukarıdaki verilerden yola çıkarak obezite ile COVID-19 mortalitesi arasındaki olası ilişkiler incelenmiştir.

Anahtar Kelimeler:

COVID-19, Mortalite, Obezite, Pandemi, SARS-CoV-2, mortality, obesity, pandemic

THE EFFECT OF OBESITY ON MORTALITY IN COVID-19 PATIENTS

The COVID-19 pandemic has caused a major global health crisis. The total number of cases detected at the global level has exceeded 200 million. It resulted in more than fourmillion deaths. Lymphopenia and impaired immune response are seen in this severe respiratory infection caused by the SARS-CoV-2 virus. It has long been known that obesity is associated with a long recovery time and worse clinical outcomes in viral infections. In creasing data on the endocrine function of adipose tissue in recent years show that obesity should be considered not only as a risk factor but also as a disease. Studies on this subject show that obese patients and their co-morbidities maybe moreprone to develop serious conditions that require hospitalization and mechanical ventilation. Studies also indicate that special attention should be paid to reduce the morbidity and mortality associated with COVID-19 infection in the presence of obesity. In this review, possible relationships between obesity and COVID-19 mortality were examined based on the above data.

Keywords:

mortality, obesity, pandemic, COVID-19, SARS-CoV-2,

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