Emine Sümeyye ÜNAL, Ülviye GÜVENDİ AKÇINAR, Funda DOGRUMAN AL, Nehir PARLAK

Rozase ile demodeks spp., sigara ve alkol arasındaki ilişki: Vaka-kontrol çalışması

Giriş ve Amaç: Rozase etyopatogenezinde demodeks akarlarının rolü bilinmektedir. Çalışmanın amacı, rozase etyopatogenezinde demodeks akarlarının rolünü anlamak, sigara ve alkol kullanımının hastalık üzerine etkisini belirlemektir. Gereç ve Yöntem: Çalışmaya, dermatoloji polikliniğine başvuran, 18 yaş üstü 156 rozaseli hasta alındı. Rozase sınıflaması yapıldı. Çalışmada eritemotelenjiektatik tip ve papülopüstüler tip ağırlıktaydı. Kontrol grubu, polikliniğe başvuran 83 sağlıklı kişiden oluşturuldu. Tüm katılımcılara; sigara, alkol kullanımı, rozase ve blefarit aile öyküsü sorgulandı. Beden kitle indeksi hesaplandı. Tüm katılımcılarda dermatolojik muayene yapıldı. Yüzeyel standart deri biyopsi yöntemi ile demodeks spp. tespiti yapıldı. Bulgular: Rozase hastaları kontrol grubuna göre daha kiloluydu (p

Anahtar Kelimeler:

Rozase, demodeks spp, sigara, alkol.

PDF

___

1. Schaller M, Almeida LM, Bewley A, Cribier B, Dlova NC, Kautz G, vd. Rosacea treatment update: recommendations from the global ROSacea COnsensus (ROSCO) panel. Br J Dermatol. 2017; 176(2):465-71.
2. Aksoy B, Ekiz O, Unal E, Ozaydin Yavuz G, Gonul M, Kulcu Cakmak S, vd. Systemic comorbidities associated with rosacea: a multicentric retrospective observational study. Int J Dermatol. 2019 Jun;58(6):722-728.
3. Tan J, Steinhoff M, Berg M, Del Rosso J, Layton A, Leyden J, vd. Shortcomings in rosacea diagnosis and classification. Br J Dermatol. 2017;176(1):197-99.
4. Tan J, Berg M. Rosacea: current state of epidemiology. J Am Acad Dermatol. 2013; 69(6 Suppl 1):S27-35.
5. Halioua B, Cribier B, Frey M, Tan J. Feelings of stigmatization in patients with rosacea. J Eur Acad Dermatol Venereol. 2017;31(1):163-68. 6. Egeberg A, Hansen PR, Gislason GH, Thyssen JP. Patients with rosacea have increased risk of depression and anxiety disorders: a Danish nationwide cohort study. Dermatology. 2016; 232(2):208-13.
7. Reinholz M, Ruzicka T, Steinhoff M, Schaller M, Gieler U, Schofer H, vd. Pathogenesis and clinical presentation of rosacea as a key for a symptom-oriented therapy. J Dtsch Dermatol Ges. 2016; 14 Suppl 6:4-15.
8. Ruini C, Sattler E, Hartmann D, Reinholz M, Ruzicka T, von Braunmuhl T. Monitoring structural changes in Demodex mites under topical Ivermectin in rosacea by means of reflectance confocal microscopy: a case series. J Eur Acad Dermatol Venereol. 2017;31(6):e299-e301.
9. Turgut Erdemir A, Gurel MS, Koku Aksu AE, Falay T, Inan Yuksel E, Sarikaya E. Demodex mites in acne rosacea: reflectance confocal microscopic study. Australas J Dermatol. 2017;58(2):e26-e30.
10. Bahadoran P. Reflectance confocal microscopy: a new key for assessing the role of Demodex in rosacea? Br J Dermatol. 2015;173(1):8-9.
11. Sattler EC, Hoffmann VS, Ruzicka T, Braunmuhl TV, Berking C. Reflectance confocal microscopy for monitoring the density of Demodex mites in patients with rosacea before and after treatment. Br J Dermatol. 2015;173(1):69-75.
12. Yamaoka T, Murota H, Tani M, Katayama I. Severe rosacea with prominent Demodex folliculorum in a patient with HIV. J Dermatol. 2014;41(2):195-6.
13. Yucel A, Yilmaz M. Investigation of the prevalance of Demodex folliculorum and Demodex brevis in rosacea patients. Turkiye Parazitol Derg. 2013;37(3):195-8.
14. Rios-Yuil JM, Mercadillo-Perez P. Evaluation of Demodex folliculorum as a risk factor for the diagnosis of rosacea in skin biopsies. Mexico's General Hospital (1975-2010). Indian J Dermatol. 2013;58(2):157.
15. Akcinar UG, Unal E, Akpinar M. Demodex spp. infestation associated with treatment-resistant chalazia and folliculitis. Turkiye Parazitol Derg. 2016;40(4):208-10.
16. Chovatiya RJ, Colegio OR. Demodicosis in renal transplant recipients. Am J Transplant. 2016;16(2):712-6.
17. Caccavale S, Di Mattia D, Ruocco E. Loco-regional immune default: The immunocompromised district in human and comparative dermatology. Clin Dermatol. 2016;34(5):654-7.
18. Guerrero-Gonzalez GA, Herz-Ruelas ME, Gomez-Flores M, Ocampo-Candiani J. Crusted demodicosis in an immunocompetent pediatric patient. Case Rep Dermatol Med. 2014;2014:458046.
19. Unal E, Akcinar UG, Basaran Y. Increased density of Demodex folliculorum may be related to additional risk factors. Arch Iran Med. 2016; 19(7):525-6.
20. Demirdag HG, Ozcan H, Gursoy S, Beker Akbulut G. The effects of sebum configuration on Demodex spp. density. Turk J Med Sci. 2016;46(5):1415-21.
21. Lacey N, Ni Raghallaigh S, Powell FC. Demodex mites-commensals, parasites or mutualistic organisms? Dermatology. 2011;222(2):128-30.
22. Aytekin S, Goktay F, Yasar S, Gizlenti S. Tips and tricks on Demodex density examination by standardized skin surface biopsy. J Eur Acad Dermatol Venereol. 2016; 30(11):e126-e128.
23. Li S, Cho E, Drucker AM, Qureshi AA, Li WQ. Obesity and risk for incident rosacea in US women. J Am Acad Dermatol. 2017;77(6):1083-1087.e5.
24. Crivellari I, Sticozzi C, Belmonte G, Muresan XM, Cervellati F, Pecorelli A, vd. SRB1 as a new redox target of cigarette smoke in human sebocytes. Free Radic Biol Med. 2017;102:47-56.
25. Rajagopalan P, Nanjappa V, Raja R, Jain AP, Mangalaparthi KK, Sathe GJ, vd. How does chronic cigarette smoke exposure affect human skin? A global proteomics study in primary human keratinocytes. Omics. 2016; 20(11):615-6.
26. Metelitsa AI, Lauzon GJ. Tobacco and the skin. Clin Dermatol. 2010; 28(4):384-90.
27. Chosidow O, Cribier B. Epidemiology of rosacea: updated data. Ann Dermatol Venereol. 2011; 138 Suppl 3:S179-183.
28. Kucukunal A, Altunay I, Arici JE, Cerman AA. Is the effect of smoking on rosacea still somewhat of a mystery? Cutan Ocul Toxicol. 2016;35(2):110-4.
29. Abram K, Silm H, Maaroos HI, Oona M. Risk factors associated with rosacea. J Eur Acad Dermatol Venereol. 2010;24(5):565-71.
30. Robledo MA, Orduz M. Hypothesis of demodicidosis rosacea flushing etiopathogenesis. Med Hypotheses. 2015;84(4):408-12.
31. Cribier B. Pathophysiology of rosacea: redness, telangiectasia, and rosacea. Ann Dermatol Venereol. 2011;138 Suppl 3:S184-191.
32. Lacey N, Delaney S, Kavanagh K, Powell FC. Mite-related bacterial antigens stimulate inflammatory cells in rosacea. Br J Dermatol. 2007; 157(3):474-81.
33. O'Reilly N, Menezes N, Kavanagh K. Positive correlation between serum immunoreactivity to Demodex-associated Bacillus proteins and erythematotelangiectatic rosacea. Br J Dermatol. 2012;167(5):1032-6.
34. Porta Guardia CA. Demodex folliculorum: its association with oily skin surface rather than rosacea lesions. Int J Dermatol. 2015;54(1):e14-17.
35. Zhou M, Xie H, Cheng L, Li J. Clinical characteristics and epidermal barrier function of papulopustular rosacea: A comparison study with acne vulgaris. Pak J Med Sci. 2016; 32(6):1344-8.
36. Jarmuda S, McMahon F, Zaba R, O'Reilly N, Jakubowicz O, Holland A, vd. Correlation between serum reactivity to Demodex-associated Bacillus oleronius proteins, and altered sebum levels and Demodex populations in erythematotelangiectatic rosacea patients. J Med Microbiol. 2014; 63(Pt 2):258-62.
37. Scribano ML, Prantera C. Antibiotics and inflammatory bowel diseases. Dig Dis. 2013;31(3-4):379-84.
38. Turan N, Kapicioglu Y, Sarac G. The effect of skin sebum, pH, and moisture on Demodex infestation in acne vulgaris and rosacea patients. Turkiye Parazitol Derg. 2017;41(3):143-7.
39. Kilic Muftuoglu I, Aydın Akova Y. Clinical findings, follow-up and treatment results in patients with ocular rosacea. Turk J Ophthalmol. 2016;46(1):1-6.
40. Kabatas N, Dogan AS, Kabatas EU, Acar M, Bicer T, Gurdal C. The effect of Demodex infestation on blepharitis and the ocular symptoms. Eye Contact Lens. 2017;43(1):64-7.