Bu 9all~ma, fizik tedavi uygulanan gonartrozlu hastalara intra-artikuler olarak verilen sodyum hiyaluronanmetkilerini ara~tmnak amac/yla yaplldl. Amenkan Romatoloii Ko/eii Diz Osteoartriti tam ktiterlerine goregonartroz tamsl konan 40 hasta fizik tedavi programma almdl. Daha sonra hasta/ar rastgele se9i/erek 20'~erki~ilik iki gruba aynldl. I. gruba yalmzca fizik tedavi uygulamp kontrol grubu olarak almdl. II. gruba ise fiziktedavi ile birJikte tedavinin 1., 7., ve 14. gunlerinde intra-artikuler sodyum hyaluronan veri/di.Deger/endirme krilerleti olarak tedaviden once ve tedavi slrasmda 7., 14., ve 21. gunlerde; istirahatte agn,gece agnsl, dirence kaf§1 ago, palpasyonla agn ve yurumek/e agn degerleri, sabah tutuklugu suresi, eklemhareket apklJ[jl dl'lumleri, kuadriseps kasl a{wl1k kaldmna gucu, eklem ve uyluk gevresi dl9umleri, 15 metreyuriime zamam, diz 'l6kme, 'lome/me, merdiven 91kma ve inme gibi gunlUk ya~am aktiviteleti ve fonksiyonelklSltianma proWi kullamldl. Ayoca ek/emde effuzyon varl/gl da degerlendirildi.Tedavi sonrasmda her iki gruptaki agn degerleri, sabah tutuklugu suresi, kuadriseps kasl a{wlJk ka/dlrmagucu, 15 metre yuriime zamam, merdiven pkma ve inme aktiviteleri ile fonksiyonel kls/tlanma profilinde r;okan/amll (p<O. 00 1), diz 'lokme ve 'lome/me aktivitelerinde anlamll (p<0.01) iyi/e~meler elde edildi. Eklem'levresi ve uyluk gevresi ol9umlerindeki iyile~meler ise anlamslzdl (p>0.05). Diz eklemlerinde hareket klsltlilig/ve effuzyonu bulunan vaka say/sl az ol1:lugundan bu parametre/er istatistiksel olarak degerlendirilemedi.Iki grup kaf§lla~t/(/ldlgmda; istirahatte ag(/, gece ag(/sl ve yurumekle agn degerleri ile fonksiyonel klsltlanmaprofilinde meydana gelen iyile§me, II. grupta I. gruba g6re daha anlamllyd/. (slfas/yla p<0.01, p<O.05, p<O.01,p<0.05). Ancak diger kJinik parametrelerde iki grup arasmda anlamll fark bufunamadl (p>O.05).Sonu9 olarak, gonartrozda intra-artikuler sodyum hyaluronanm ozellikle agnnm azaltllmasl ve fonksiyonelklsltllll{Jm duzeltilmesinde etkili ve guvenli bir yontem oldugu, bu nedenle klasik fizik tedavi programluygulanan gonartrozlu hastalara fizik tedavi lie birlikte intra-artikUler sodyum hyaluronan verilmesinin faydallolaeagl kamsma vanldl.Anahtar Kelimeler: Sodyum-Hyaluronan, Gonartroz, Fizik tedavi SUMMARYThis study vas performed to determine the effects of intra-articular Sodium-Hyaluronate in patient withgonarthritis that had pyhsicial therapy. A physical therapy programme was performed in forty patients thatdiagnosed as gonarthritis according to American Collage of Rheumatology criteria. And then patients wereallocated randomly to two parellel groups of equal size. First group was received only physicial therapy andre~arded as control group. Intra-articular Sodium-Hyaluronate was administered to the second group on the15, t h, and 14th days in addition to them.Evaluation criten'a at baseline and at t h, 14th and 21th were rest pain, night pain, pain underload, touch painand walking pain, the duration of morning stiffness, range of motion measurements, power of lifting mass ofquadn'ceps muscle, the measurement ofjoint and thigh ring size, 15 meters walking time, daily living activitiessuch as kneeling, squatting, going up stairs, going down stairs and sickness impact profile. The presence ofjoint effusion was also evaluated.After teratmem in both groups, there were very significant improvements in pain score, morning stiffness, thepower of lifting mass of quadriceps muscle, 15 meters walking time, going up stairs and going down stairs,and sickness impack profile (p<0.001). There were also significant improvements in kneeling and squattingactivities (p<0.01). There was no significant improvement in the measurement of joint and thigh ring size(p>0.05). The measurements of range of motion and presence of ioint effusion were not able to evaluatedbecause the number of the patients that had limited joint movements and joint effusion was not enough.In comparing the two groups the improvements in rest pain, night pain, walking pain and sickness impactprofile were more significant in second group according to first group (respectively p<0.01, p<0.05, p<0.01,p<0.05). But there was no significant difference in other clinicaf parameters between two groups (p>0.05).It was concluted that intra-articular Sodium-Hyaluronate is an effective and safe method in gonarthritisespecially in decreasing the pain and improving sickness impact profile. Sodium-Hyaluronate may thereforebe a useful additional therapy for the patients with gonartrosis treated with physical therapyKey Words: Sodium-Hyaluronan, Gonarthrosis, Physical Therapy