Reaktif Hiperplazi ve Rekürrent Tonsillitlerde Lusigenin - Serbest Oksijen Radikallerinin Karşılaştırılması

Giriş ve Amaç: kronik tonsilite bağlı Tonsillektomi (T), Kulak Burun Boğaz hekimlerinin en sık yaptıkları ameliyatlardandır. Halen kronik tonsillit ve tonsil hipertrofisi patogenizindeki faklılıklar tam olarak bilinmemektedir. Tonsil hipertrofisi ve kronik tonsillit hastalarında serbest okisjen radikallerinin seviyelerinin karşılaştırılması ve serbest okisjen radikallerinin kronik tonsiillit patogenezindeki rolünün araştırılması bu çalışmada amaçlanmıştır.Gereç ve yöntem: Çalışmaya Paradise kriterlerine göre Tonsillektomi (T) endikasyonu konulan ve opere edilen 40 hasta alındı. Operasyon materyallerine histopatolojik inceleme ve serbest oksijen radikalleriden süperoksit ölçümleri yapıldı.Bulgular: Histopatolojik bulgulara göre; 28 (%70) hastadan oluşan aktif yada kronik tonsilitli diğeri ise 12 (%30) hastadan oluşan reaktif folliküler hiperplazili olarak iki gruba ayrıldı. Kronik tonsilitli grubun lusigenin-serbest oksijen radikal (Luc-SOR) değeri 82.29+-32.3 Auc, reaktif folliküler hiperplazi’li grubun ise 50.76+-7.95 Auc bulundu. Luc-SOR değeri karşılaştırıldığında kronik tonsillitli grupta anlamlı derecede (p=0.001) yüksek olduğu belirlendi. Sonuç: Serbest oksijen radikalleri tonsiller patolojilerde önemli rol oynamaktadır. Tonsil hipertrofisi ve kronik tonsillit hastalarının tonsil dokusundan ölçülen Luc-SOR değerlerinin farklı olması bu iki hastalığın patogenezinin de farklı olduğunu göstermektedir.

Anahtar Kelimeler:

Tonsillektomi, Kronik Tonsilit, Serbest Oksijen Radikalleri

A Comparison of Lucigenin - Free Oxygen Radicals in Reactive Hyperplasia and Recurrent Tonsillitis

Aim and Background: Today, tonsillectomy (T) used for chronic tonsillitis is among the most common surgery type that ear, nose, and throat physicians perform. The differences in the pathogenesis of chronic tonsillitis and tonsil hypertrophy are still unknown. This study aimed to compare the levels of free oxygen radicals in patients with tonsil hypertrophy and chronic tonsillitis and to investigate the role of free oxygen radicals in the pathogenesis of chronic tonsillitis.Materials and Method: The study included 40 patients who had chronic tonsillitis indications based on Paradise criteria, and T was performed. Operation materials were histopathologically examined, and their free oxygen radicals (FOR) levels were measured. Results: Based on the histopathological results, the participants were divided into two groups: one including 28 (70%) patients who had active or chronic tonsillitis, the other including 12 (30%) patients with reactive follicular hyperplasia. Lucigenin - free oxygen radicals (Luc-FOR) levels of the group with chronic tonsillitis and that of the group with reactive follicular hyperplasia were 82.29±32.3 Auc and 50.76±7.95 Auc, respectively. Luc-FOR values were found to be significantly higher in the group with chronic tonsillitis (p=0.001). Conclusion: Free oxygen radicals play an essential role in tonsillar pathologies. Differences in the Luc-FOR levels measured from tonsillar tissue in patients with tonsil hypertrophy and chronic tonsillitis demonstrate that the pathogenesis of these two diseases is different.

Keywords:

tonsillectomy, chronic tonsillitis, free oxygen radicals,

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