This issue is the outcome of an effort to understand the foreign policy dynamics of the U.S. in this rapidly changing global atmosphere. Through a multi-dimensional academic approach, it aims to examine the impact of various systemic, regional and domestic challenges on the course of recent American foreign policy. The six articles that contribute to this issue assess the foreign policy practices of the U.S. especially during the Obama and Trump eras, but do not exclude the historical background that continues to shape the country’s current policies.