This article approaches the Organization of Turkic States (OTS) through the lens of Samuel P. Huntington’s civilizational approach. It discusses the outcomes of the Istanbul Summit held in 2021, including important changes in the activities of the organization and the historical decisions adopted by the heads of states. Additionally, it makes prognoses on the future of security cooperation among the Turkic states by assessing the current status of their cooperation and the likelihood of future development in this area. Next, it focuses on the role of the Secretary-General in the development and formation of the OTS. Finally, the article explores the main directions of the organization’s future development in an increasingly globalized world.